A comprehensive insight into the anti-inflammatory properties of dapsone

被引:22
作者
Khalilzadeh, Mina [1 ,2 ]
Shayan, Maryam [1 ,2 ]
Jourian, Sina [1 ,2 ]
Rahimi, Mohammad [1 ,2 ]
Sheibani, Mohammad [3 ,4 ]
Dehpour, Ahmad Reza [1 ,2 ]
机构
[1] Univ Tehran Med Sci, Expt Med Res Ctr, Tehran, Iran
[2] Univ Tehran Med Sci, Sch Med, Dept Pharmacol, Tehran 13145784, Iran
[3] Iran Univ Med Sci, Sch Med, Dept Pharmacol, Tehran 1449614525, Iran
[4] Iran Univ Med Sci, Razi Drug Res Ctr, Sch Med, Tehran, Iran
关键词
Dapsone; Anti-inflammatory; Oxidative stress; Experimental models; Inflammation; METHIONYL-LEUCYL-PHENYLALANINE; ADVERSE DRUG-REACTIONS; NEUTROPHIL ADHERENCE; DOUBLE-BLIND; INHIBITION; GENERATION; MYELOPEROXIDASE; RAT; CHEMOTAXIS; PEMPHIGUS;
D O I
10.1007/s00210-022-02297-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The 4,4'-diaminodiphenyl sulfone (DDS), also known as dapsone, is traditionally used as a potent anti-bacterial agent in clinical management of leprosy. For decades, dapsone has been among the first-line medications used in multidrug treatment of leprosy recommended by the World Health Organization (WHO). Shortly after dapsone's discovery as an antibiotic in 1937, the dual function of dapsone (anti-microbial and anti-inflammatory) was elucidated. Dapsone exerts its anti-bacterial effects by inhibiting dihydrofolic acid synthesis, leading to inhibition of bacterial growth, while its anti-inflammatory properties are triggered by inhibiting reactive oxygen species (ROS) production, reducing the effect of eosinophil peroxidase on mast cells and downregulating neutrophil-mediated inflammatory responses. Among the leading mechanisms associated with its anti-microbial/anti-protozoal effects, dapsone clearly has multiple antioxidant, anti-inflammatory, and anti-apoptotic functions. In this regard, it has been described in treating a wide variety of inflammatory and infectious skin conditions. Previous reports have explored different molecular targets for dapsone and provided insight into the anti-inflammatory mechanism of dapsone. This article reviews several basic, experimental, and clinical approaches on anti-inflammatory effect of dapsone.
引用
收藏
页码:1509 / 1523
页数:15
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