Induced Pluripotent Stem Cell-Derived Cardiomyocytes Boutique Science or Valuable Arrhythmia Model?

被引：88
作者：
Knollmann, Bjoern C. [1 ]
机构：
[1] Vanderbilt Univ, Div Clin Pharmacol, Sch Med, Dept Med, Nashville, TN 37232 USA
来源：
CIRCULATION RESEARCH | 2013年 / 112卷 / 06期
基金：
美国国家卫生研究院;
关键词：
arrhythmia mechanism; human ventricular myocytes; induced pluripotent stem cells; LONG-QT SYNDROME; POLYMORPHIC VENTRICULAR-TACHYCARDIA; SUDDEN CARDIAC DEATH; SARCOPLASMIC-RETICULUM; FUNCTIONAL-PROPERTIES; CA2+; MYOCYTES; DRUGS;
D O I：
10.1161/CIRCRESAHA.112.300567
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This article reviews the strengths and limitations of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) as models of cardiac arrhythmias. Specifically, the article attempts to answer the following questions: Which clinical arrhythmias can be modeled by iPSC-CM? How well can iPSC-CM model adult ventricular myocytes? What are the strengths and limitations of published iPSC-CM arrhythmia models? What new mechanistic insight has been gained? What is the evidence that would support using iPSC-CM to personalize antiarrhythmic drug therapy? The review also discusses the pros and cons of using the iPSC-CM technology for modeling specific genetic arrhythmia disorders, such as long QT syndrome, Brugada Syndrome, or Catecholaminergic Polymorphic Ventricular Tachycardia. (Circ Res. 2013;112:969-976.)
引用
收藏
页码：969 / 976
页数：8
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