Synthesis of α-Ketothioamides via Willgerodt-Kindler Reaction of Arylglyoxals with Amines and Sulfur under Solvent-Free Conditions

被引：26

作者：

Eftekhari-Sis, Bagher ^{[1
]}

Khajeh, Saleh Vahdati ^{[1
]}

Buyukgungor, Orhan ^{[2
]}

机构：

[1] Univ Maragheh, Dept Chem, Maragheh, Iran

[2] Ondokuz Mayis Univ, Dept Phys, TR-55139 Samsun, Turkey

来源：

SYNLETT | 2013年 / 24卷 / 08期

关键词：

alpha-ketothioamides; Willgerodt-Kindler reaction; arylglyoxals; green chemistry; solvent-free; CONJUGATE ADDITION; KINETIC RESOLUTION; THIOAMIDES; THIONATION; EFFICIENT; FACILE; CYCLIZATION; THIOPHENES; SUBSTRATE; CATALYST;

D O I：

10.1055/s-0032-1316897

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Willgerodt-Kindler reaction of arylglyoxal hydrates with secondary amines and elemental sulfur under solvent-free conditions at 80 degrees C is developed, in which alpha-ketothioamides are obtained in 70-90% yield in 0.6-1 hour. The X-ray crystal-structure analysis for one compound was obtained.

引用

页码：977 / 980

页数：4

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