Synthesis of α-Ketothioamides via Willgerodt-Kindler Reaction of Arylglyoxals with Amines and Sulfur under Solvent-Free Conditions

被引：26
作者：
Eftekhari-Sis, Bagher [1 ]
Khajeh, Saleh Vahdati [1 ]
Buyukgungor, Orhan [2 ]
机构：
[1] Univ Maragheh, Dept Chem, Maragheh, Iran
[2] Ondokuz Mayis Univ, Dept Phys, TR-55139 Samsun, Turkey
来源：
SYNLETT | 2013年 / 24卷 / 08期
关键词：
alpha-ketothioamides; Willgerodt-Kindler reaction; arylglyoxals; green chemistry; solvent-free; CONJUGATE ADDITION; KINETIC RESOLUTION; THIOAMIDES; THIONATION; EFFICIENT; FACILE; CYCLIZATION; THIOPHENES; SUBSTRATE; CATALYST;
D O I：
10.1055/s-0032-1316897
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Willgerodt-Kindler reaction of arylglyoxal hydrates with secondary amines and elemental sulfur under solvent-free conditions at 80 degrees C is developed, in which alpha-ketothioamides are obtained in 70-90% yield in 0.6-1 hour. The X-ray crystal-structure analysis for one compound was obtained.
引用
收藏
页码：977 / 980
页数：4
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