MiRNA inhibition in tissue engineering and regenerative medicine

被引：67

作者：

Beavers, Kelsey R. ^{[1
]}

Nelson, Christopher E. ^{[2
]}

Duvall, Craig L. ^{[1
,3
]}

机构：

[1] Vanderbilt Univ, Interdisciplinary Grad Program Mat Sci, Nashville, TN 37235 USA

[2] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[3] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2015年 / 88卷

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

MiRNA; Anti-miR; MiRNA inhibition; Tissue engineering; Regenerative medicine; BONE MORPHOGENETIC PROTEIN-2; SMALL-MOLECULE INHIBITORS; PEPTIDE NUCLEIC-ACIDS; IN-VIVO; GENE DELIVERY; SATELLITE CELLS; ANTISENSE OLIGONUCLEOTIDES; OSTEOGENIC DIFFERENTIATION; TARGETING MICRORNAS; NONHUMAN-PRIMATES;

D O I：

10.1016/j.addr.2014.12.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

MicroRNAs (miRNAs) are noncoding RNAs that provide an endogenous negative feedback mechanism for translation of messenger RNA (mRNA) into protein. Single miRNAs can regulate hundreds of mRNAs, enabling miRNAs to orchestrate robust biological responses by simultaneously impacting multiple gene networks. MiRNAs can act as master regulators of normal and pathological tissue development, homeostasis, and repair, which has motivated expanding efforts toward the development of technologies for therapeutically modulating miRNA activity for regenerative medicine and tissue engineering applications. This review highlights the tools currently available for miRNA inhibition and their recent therapeutic applications for improving tissue repair. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：123 / 137

页数：15

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