Improving Vaccine and Immunotherapy Design Using Biomaterials

被引：146

作者：

Bookstaver, Michelle L. ^{[1
]}

Tsai, Shannon J. ^{[1
]}

Bromberg, Jonathan S. ^{[2
,3
,4
,5
]}

Jewell, Christopher M. ^{[1
,4
,5
,6
]}

机构：

[1] Univ Maryland, Fischell Dept Bioengn, 8228 Paint Branch Dr, College Pk, MD 20742 USA

[2] Univ Maryland, Dept Surg, Sch Med, 29 South Greene St, Baltimore, MD 21201 USA

[3] Univ Maryland, Ctr Vasc & Inflammatory Dis, Sch Med, 800 West Baltimore St, Baltimore, MD 21201 USA

[4] Univ Maryland, Dept Microbiol & Immunol, Sch Med, 685 West Baltimore St, Baltimore, MD 21201 USA

[5] Marlene & Stewart Greenebaum Canc Ctr, 22 South Greene St, Baltimore, MD 21201 USA

[6] United States Dept Vet Affairs, 10 North Greene St, Baltimore, MD 21201 USA

来源：

TRENDS IN IMMUNOLOGY | 2018年 / 39卷 / 02期

基金：

美国国家科学基金会;

关键词：

LYMPH-NODE MICROENVIRONMENT; T-CELLS; POLYELECTROLYTE MULTILAYERS; IMMUNE-RESPONSE; DENDRITIC CELLS; IN-VIVO; CROSS-PRESENTATION; ANTIGEN; NANOPARTICLES; DELIVERY;

D O I：

10.1016/j.it.2017.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polymers, lipids, scaffolds, microneedles, and other biomaterials are rapidly emerging as technologies to improve the efficacy of vaccines against infectious disease and immunotherapies for cancer, autoimmunity, and transplantation. New studies are also providing insight into the interactions between these materials and the immune system. This insight can be exploited for more efficient design of vaccines and immunotherapies. Here, we describe recent advances made possible through the unique features of biomaterials, as well as the important questions for further study.

引用

页码：135 / 150

页数：16

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