Is atrial fibrillation an inflammatory disorder?

被引：477

作者：

Boos, CJ

Anderson, RA

Lip, GYH ^{[1
]}

机构：

[1] City Hosp, Univ Dept Med, Haemostasis Thrombosis & Vasc Biol Unit, Birmingham B18 7QH, W Midlands, England

[2] Univ Wales Hosp, Cardiff CF14 4XN, S Glam, Wales

来源：

EUROPEAN HEART JOURNAL | 2006年 / 27卷 / 02期

关键词：

atrial fibrillation; inflammation; angiotensin II; prevention; novel therapies;

D O I：

10.1093/eurheartj/ehi645

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is mounting evidence to support the influence of inflammation in the pathogenesis of atrial fibrillation (AF). Indeed, AF is associated with increased levels of known inflammatory markers, even after adjustment for confounding factors. The renin-angiotensin-aldosterone system (RAAS) appears to play a key role in this process. Atrial biopsies from patients with AF have also confirmed the presence of inflammation. Furthermore, there is preliminary evidence to support a number of drug therapies that have the potential to reduce the clinical burden of AF. In this review, we present an overview of the evidence supporting a link between inflammation and AF, and some of the drug therapies, such as the angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, steroids, fish oils, and vitamin C, that might be efficacious in the prevention of AF by modulating inflammatory pathways.

引用

页码：136 / 149

页数：14

共 185 条

[1] Relation of an exaggerated rise in white blood cells after coronary bypass or cardiac valve surgery to development of atrial fibrillation postoperatively [J].