Large-field high-speed polarization sensitive spectral domain OCT and its applications in ophthalmology

被引：41

作者：

Zotter, Stefan ^{[1
]}

Pircher, Michael ^{[1
]}

Torzicky, Teresa ^{[1
]}

Baumann, Bernhard ^{[1
]}

Yoshida, Hirofumi ^{[3
]}

Hirose, Futoshi ^{[3
]}

Roberts, Philipp ^{[2
]}

Ritter, Markus ^{[2
]}

Schuetze, Christopher ^{[2
]}

Goetzinger, Erich ^{[1
]}

Trasischker, Wolfgang ^{[1
]}

Vass, Clemens ^{[3
]}

Schmidt-Erfurth, Ursula ^{[2
]}

Hitzenberger, Christoph K. ^{[1
]}

机构：

[1] Med Univ Vienna, Ctr Med Phys & Biomed Engn, A-1090 Vienna, Austria

[2] Med Univ Vienna, Dept Ophthalmol & Optometry, A-1090 Vienna, Austria

[3] Canon Inc, Tokyo, Japan

来源：

BIOMEDICAL OPTICS EXPRESS | 2012年 / 3卷 / 11期

关键词：

NERVE-FIBER LAYER; OPTICAL COHERENCE TOMOGRAPHY; SCANNING LASER POLARIMETRY; RETINAL-PIGMENT EPITHELIUM; IN-VIVO; RESOLVED BIREFRINGENCE; GLAUCOMA; THICKNESS; TISSUE; AREA;

D O I：

10.1364/BOE.3.002720

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a novel spectral domain polarization sensitive OCT system (PS-OCT) that operates at an A-scan rate of 70 kHz and supports scan angles of up to 40 degrees x 40 degrees. The high-speed imaging allows the acquisition of up to 1024 x 250 A-scans per 3D scan, which, together with the large field of view, considerably increases the informative value of the images. To demonstrate the excellent performance of the new PS-OCT system, we imaged several healthy volunteers and patients with various diseases such as glaucoma, AMD, Stargardt's disease, and albinism. The results are compared with clinically established methods such as scanning laser polarimetry and autofluorescence. (C) 2012 Optical Society of America

引用

页码：2720 / 2732

页数：13

共 34 条

[1] Imaging of the Retinal Pigment Epithelium in Age-Related Macular Degeneration Using Polarization-Sensitive Optical Coherence Tomography [J].

Ahlers, Christian ;

Goetzinger, Erich ;

Pircher, Michael ;

Golbaz, Isabelle ;

Prager, Franz ;

Schuetze, Christopher ;

Baumann, Bernhard ;

Hitzenberger, Christoph K. ;

Schmidt-Erfurth, Ursula .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (04) :2149-2157

[2]

[Anonymous], 2008, OPTICAL COHERENCE TO

[3] Single camera based spectral domain polarization sensitive optical coherence tomography [J].

Baumann, Bernhard ;

Goetzinger, Erich ;

Pircher, Michael ;

Hitzenberger, Christoph K. .

OPTICS EXPRESS, 2007, 15 (03) :1054-1063

[4] Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography [J].

Baumann, Bernhard ;

Goetzinger, Erich ;

Pircher, Michael ;

Sattmann, Harald ;

Schuetze, Christopher ;

Schlanitz, Ferdinand ;

Ahlers, Christian ;

Schmidt-Erfurth, Ursula ;

Hitzenberger, Christoph K. .

JOURNAL OF BIOMEDICAL OPTICS, 2010, 15 (06)

[5] BIREFRINGENCE OF THE HUMAN FOVEAL AREA ASSESSED INVIVO WITH MUELLER-MATRIX ELLIPSOMETRY [J].

BRINK, HBK ;

VANBLOKLAND, GJ .

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 1988, 5 (01) :49-57

[6] Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography [J].

Cense, B ;

Chen, TC ;

Park, BH ;

Pierce, MC ;

de Boer, JF .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 (08) :2606-2612

[7] In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography [J].

Cense, B ;

Chen, TC ;

Park, BH ;

Pierce, MC ;

de Boer, JF .

OPTICS LETTERS, 2002, 27 (18) :1610-1612

[8] Scanning laser polarimetry with variable corneal compensation in the area of apparently normal hemifield in eyes with normal-tension glaucoma [J].

Choi, Jaewan ;

Cho, Hyun-soo ;

Lee, Chang Hwan ;

Kook, Michael S. .

OPHTHALMOLOGY, 2006, 113 (11) :1954-1960

[9] Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography [J].

deBoer, JF ;

Milner, TE ;

vanGemert, MJC ;

Nelson, JS .

OPTICS LETTERS, 1997, 22 (12) :934-936

[10] SPATIALLY RESOLVED BIREFRINGENCE OF THE RETINAL NERVE-FIBER LAYER ASSESSED WITH A RETINAL LASER ELLIPSOMETER [J].

DREHER, AW ;

REITER, K ;

WEINREB, RN .

APPLIED OPTICS, 1992, 31 (19) :3730-3735

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