Tools and applications in synthetic biology

被引：35

作者：

MacDonald, I. Cody ^{[1
]}

Deans, Tara L. ^{[1
]}

机构：

[1] Univ Utah, Dept Bioengn, Biopolymers Res Bldg,108B,20 South 2030 East, Salt Lake City, UT 84112 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2016年 / 105卷

基金：

美国国家科学基金会;

关键词：

Synthetic biology; Genetic circuits; Cell therapy; Gene networks; GENE NETWORKS; MAMMALIAN-CELLS; PROTEIN INTERACTIONS; ESCHERICHIA-COLI; MARKUP LANGUAGE; BLOOD-GLUCOSE; T-CELLS; RNA; GENOME; CIRCUITS;

D O I：

10.1016/j.addr.2016.08.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Advances in synthetic biology have enabled the engineering of cells with genetic circuits in order to program cells with new biological behavior, dynamic gene expression, and logic control. This cellular engineering progression offers an array of living sensors that can discriminate between cell states, produce a regulated dose of therapeutic biomolecules, and function in various delivery platforms. In this review, we highlight and summarize the tools and applications in bacterial and mammalian synthetic biology. The examples detailed in this review provide insight to further understand genetic circuits, how they are used to program cells with novel functions, and current methods to reliably interface this technology in vivo; thus paving the way for the design of promising novel therapeutic applications. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：20 / 34

页数：15

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