Impact of testosterone on body fat composition

被引:68
作者
De Maddalena, Chiara [2 ]
Vodo, Stella [1 ]
Petroni, Anna [3 ]
Aloisi, Anna Maria [1 ]
机构
[1] Univ Siena, Dept Physiol, Sect Neurosci & Appl Physiol, I-53100 Siena, Italy
[2] San Carlo Clin, Milan, Italy
[3] Univ Milan, Dept Pharmacol Sci, Milan, Italy
关键词
LATE-ONSET HYPOGONADISM; METABOLIC SYNDROME; INSULIN-RESISTANCE; ADIPONECTIN LEVELS; ANDROGEN LEVELS; ADIPOSE-TISSUE; PLASMA GHRELIN; ADIPOCYTE DIFFERENTIATION; MEDIATED IMPROVEMENT; LEPTIN CONCENTRATION;
D O I
10.1002/jcp.24096
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
An excessive food supply has resulted in an increasing prevalence of overweight and obesity, conditions accompanied by serious health problems. Several studies have confirmed the significant inverse correlation between testosterone and obesity. Indeed after decades of intense controversy, a consensus has emerged that androgens are important regulators of fat mass and distribution in mammals and that androgen status affects cellularity in vivo. The high correlation of testosterone levels with body composition and its contribution to the balance of lipid metabolism are also suggested by the fact that testosterone lowering is associated with important clinical disorders such as dyslipidemia, atherosclerosis, cardiovascular diseases, metabolic syndrome and diabetes. In contrast, testosterone supplementation therapy in hypogonadic men has been shown to improve the lipid profile by lowering cholesterol, blood sugar and insulin resistance. Leptin, ghrelin and adiponectin are some of the substances related to feeding as well as androgen regulation. Thus, complex and delicate mechanisms appear to link androgens with various tissues (liver, adipose tissue, muscles, coronary arteries and heart) and the subtle alteration of some of these interactions might be the cause of correlated diseases. This review underlines some aspects regarding the high correlations between testosterone physiology and body fat composition. J. Cell. Physiol. 227: 37443748, 2012. (c) 2012 Wiley Periodicals, Inc.
引用
收藏
页码:3744 / 3748
页数:5
相关论文
共 78 条
[1]  
Al-Harithy RN, 2004, SAUDI MED J, V25, P1086
[2]  
Aloisi Anna Maria, 2009, Psychoneuroendocrinology, V34 Suppl 1, pS162, DOI 10.1016/j.psyneuen.2009.05.013
[3]  
Bai J, 2011, BIOCHEM MEDICA, V21, P65
[4]   Ghrelin and reproduction: a novel signal linking energy status and fertility? [J].
Barreiro, ML ;
Tena-Sempere, M .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2004, 226 (1-2) :1-9
[5]   Cellular location and hormonal regulation of ghrelin expression in rat testis [J].
Barreiro, ML ;
Gaytán, F ;
Caminos, JE ;
Pinilla, L ;
Casanueva, FF ;
Aguilar, E ;
Diéguez, C ;
Tena-Sempere, M .
BIOLOGY OF REPRODUCTION, 2002, 67 (06) :1768-1776
[6]   Regulation of Wnt signaling during adipogenesis [J].
Bennett, CN ;
Ross, SE ;
Longo, KA ;
Bajnok, L ;
Hemati, N ;
Johnson, KW ;
Harrison, SD ;
MacDougald, OA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (34) :30998-31004
[7]   ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism [J].
Berg, AH ;
Combs, TP ;
Scherer, PE .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2002, 13 (02) :84-89
[8]   Testosterone dose-response relationships in healthy young men [J].
Bhasin, S ;
Woodhouse, L ;
Casaburi, R ;
Singh, AB ;
Bhasin, D ;
Berman, N ;
Chen, XH ;
Yarasheski, KE ;
Magliano, L ;
Dzekov, C ;
Dzekov, J ;
Bross, R ;
Phillips, J ;
Sinha-Hikim, I ;
Shen, RQ ;
Storer, TW .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2001, 281 (06) :E1172-E1181
[9]   EXPANSION OF ADIPOSE-TISSUE STORAGE CAPACITY AT DIFFERENT AGES IN RATS [J].
BJORNTORP, P ;
KARLSSON, M ;
PETTERSSON, P .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1982, 31 (04) :366-373
[10]  
Bjorntorp P, 1974, Horm Metab Res, VSuppl 4, P77