The regulation of mRNA stability in mammalian cells: 2.0

被引：186

作者：

Wu, Xiangyue ^{[1
]}

Brewer, Gary ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet Microbiol & Immunol, Piscataway, NJ 08854 USA

来源：

GENE | 2012年 / 500卷 / 01期

关键词：

mRNA degradation pathways; RNA surveillance; AU-rich elements; RNA-binding proteins; Noncoding RNAs; EXON JUNCTION COMPLEX; ACTIVATED PROTEIN-KINASE; 3' UNTRANSLATED REGION; GU-RICH ELEMENTS; BINDING-PROTEIN; POSTTRANSCRIPTIONAL REGULATION; MEDIATED DECAY; TRANSLATIONAL REPRESSION; QUALITY-CONTROL; NUCLEAR IMPORT;

D O I：

10.1016/j.gene.2012.03.021

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Messenger RNA decay is an essential step in gene expression to set mRNA abundance in the cytoplasm. The binding of proteins and/or noncoding RNAs to specific recognition sequences or secondary structures within mRNAs dictates mRNA decay rates by recruiting specific enzyme complexes that perform the destruction processes. Often, the cell coordinates the degradation or stabilization of functional subsets of mRNAs encoding proteins collectively required for a biological process. As well, extrinsic or intrinsic stimuli activate signal transduction pathways that modify the mRNA decay machinery with consequent effects on decay rates and mRNA abundance. This review is an update to our 2001 Gene review on mRNA stability in mammalian cells, and we survey the enormous progress made over the past decade. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：10 / 21

页数：12

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