Diagnostics and therapeutic implications of gut microbiota alterations in cardiometabolic diseases

被引：37

作者：

Schiattarella, Gabriele G. ^{[1
,2
]}

Sannino, Anna ^{[2
,3
]}

Esposito, Giovanni ^{[2
]}

Perrino, Cinzia ^{[2
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med Cardiol, 6000 Harry Hines Blvd,NB11-208, Dallas, TX 75390 USA

[2] Univ Naples Federico II, Div Cardiol, Dept Adv Biomed Sci, Via Pansini 5, I-80131 Naples, Italy

[3] Baylor Heart & Vasc Hosp, Baylor Res Inst, Dallas, TX USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2019年 / 29卷 / 03期

关键词：

Cardiovascular risk; Heart failure; Metagenomics; Microbiome; Diet; Trimethylamine n-oxide; TRIMETHYLAMINE-N-OXIDE; PROTEIN-COUPLED RECEPTOR; BILE-ACID METABOLISM; BLOOD-PRESSURE; PROGNOSTIC VALUE; OBESITY; DIET; HYPERTENSION; SECRETION; GLUCOSE;

D O I：

10.1016/j.tcm.2018.08.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alterations in gut microbiota composition and its metabolic activity are emerging as one of the most powerful determinants of cardiovascular disease. Although our knowledge of the precise molecular mechanisms by which gut microbiota influences cardiometabolic homeostasis is still limited, a growing body of knowledge has recently been uncovered about the potential modulation of microbiome for cardiovascular diagnostic and therapeutic aspects. The multitude of interactions between the microorganisms inhabiting the digestive tract and the host has been recognized crucial in the development and progression of atherosclerosis, obesity, diabetes and hypertension. Here, we summarize the role of gut microbiota in host physiology as well as in the pathophysiology of the most common cardio-metabolic disorders, discussing the potential therapeutic opportunities offered by interventions aimed at modifying microbiome composition and activity. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：141 / 147

页数：7

共 86 条

[1] Alterations in the gut microbiota can elicit hypertension in rats [J].

Adnan, Sareema ;

Nelson, James W. ;

Ajami, Nadim J. ;

Venna, Venugopal R. ;

Petrosino, Joseph F. ;

Bryan, Robert M., Jr. ;

Durgan, David J. .

PHYSIOLOGICAL GENOMICS, 2017, 49 (02) :96-104

[2] A clinical trial of the effects of dietary patterns on blood pressure [J].

Appel, LJ ;

Moore, TJ ;

Obarzanek, E ;

Vollmer, WM ;

Svetkey, LP ;

Sacks, FM ;

Bray, GA ;

Vogt, TM ;

Cutler, JA ;

Windhauser, MM ;

Lin, PH ;

Karanja, N .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (16) :1117-1124

[3] Enterotypes of the human gut microbiome [J].

Arumugam, Manimozhiyan ;

Raes, Jeroen ;

Pelletier, Eric ;

Le Paslier, Denis ;

Yamada, Takuji ;

Mende, Daniel R. ;

Fernandes, Gabriel R. ;

Tap, Julien ;

Bruls, Thomas ;

Batto, Jean-Michel ;

Bertalan, Marcelo ;

Borruel, Natalia ;

Casellas, Francesc ;

Fernandez, Leyden ;

Gautier, Laurent ;

Hansen, Torben ;

Hattori, Masahira ;

Hayashi, Tetsuya ;

Kleerebezem, Michiel ;

Kurokawa, Ken ;

Leclerc, Marion ;

Levenez, Florence ;

Manichanh, Chaysavanh ;

Nielsen, H. Bjorn ;

Nielsen, Trine ;

Pons, Nicolas ;

Poulain, Julie ;

Qin, Junjie ;

Sicheritz-Ponten, Thomas ;

Tims, Sebastian ;

Torrents, David ;

Ugarte, Edgardo ;

Zoetendal, Erwin G. ;

Wang, Jun ;

Guarner, Francisco ;

Pedersen, Oluf ;

de Vos, Willem M. ;

Brunak, Soren ;

Dore, Joel ;

Weissenbach, Jean ;

Ehrlich, S. Dusko ;

Bork, Peer .

NATURE, 2011, 473 (7346) :174-180

[4] Host-bacterial mutualism in the human intestine [J].

Bäckhed, F ;

Ley, RE ;

Sonnenburg, JL ;

Peterson, DA ;

Gordon, JI .

SCIENCE, 2005, 307 (5717) :1915-1920

[5] Defining the gut microbiota in individuals with periodontal diseases: an exploratory study [J].

Baeta Lourenco, Talita Gomes ;

Spencer, Sarah J. ;

Alm, Eric John ;

Vieira Colombo, Ana Paula .

JOURNAL OF ORAL MICROBIOLOGY, 2018, 10 (01)

[6] Role of the Microbiota in Immunity and Inflammation [J].

Belkaid, Yasmine ;

Hand, Timothy W. .

CELL, 2014, 157 (01) :121-141

[7] Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia [J].

Cani, P. D. ;

Neyrinck, A. M. ;

Fava, F. ;

Knauf, C. ;

Burcelin, R. G. ;

Tuohy, K. M. ;

Gibson, G. R. ;

Delzenne, N. M. .

DIABETOLOGIA, 2007, 50 (11) :2374-2383

[8] Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability [J].

Cani, P. D. ;

Possemiers, S. ;

Van de Wiele, T. ;

Guiot, Y. ;

Everard, A. ;

Rottier, O. ;

Geurts, L. ;

Naslain, D. ;

Neyrinck, A. ;

Lambert, D. M. ;

Muccioli, G. G. ;

Delzenne, N. M. .

GUT, 2009, 58 (08) :1091-1103

[9] Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway [J].

Chen, Ming-liang ;

Zhu, Xiao-hui ;

Ran, Li ;

Lang, He-dong ;

Yi, Long ;

Mi, Man-tian .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (09)

[10] Antibiotics in early life alter the murine colonic microbiome and adiposity [J].

Cho, Ilseung ;

Yamanishi, Shingo ;

Cox, Laura ;

Methe, Barbara A. ;

Zavadil, Jiri ;

Li, Kelvin ;

Gao, Zhan ;

Mahana, Douglas ;

Raju, Kartik ;

Teitler, Isabel ;

Li, Huilin ;

Alekseyenko, Alexander V. ;

Blaser, Martin J. .

NATURE, 2012, 488 (7413) :621-+

← 1 2 3 4 5 6 7 8 9 →