Biodistribution and long-term fate of silver nanoparticles functionalized with bovine serum albumin in rats

被引：73

作者：

Garza-Ocanas, Lourdes ^{[2
]}

Ferrer, Domingo A. ^{[3
]}

Burt, Justin ^{[4
]}

Diaz-Torres, Luis A. ^{[5
]}

Ramirez Cabrera, Monica ^{[2
]}

Tamez Rodriguez, Victor ^{[2
]}

Lujan Rangel, Ruben ^{[2
]}

Romanovicz, Dwight ^{[6
]}

Jose-Yacaman, Miguel ^{[1
]}

机构：

[1] Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX USA

[2] Univ Autonoma Nuevo Leon, Fac Med, Dept Farmacol & Toxicol, Monterrey Nuevo Leon, Mexico

[3] Univ Texas Austin, Microelect Res Ctr, Austin, TX 78712 USA

[4] Univ Texas Austin, Dept Chem Engn, Austin, TX 78712 USA

[5] Ctr Invest Opt, Leon, Mexico

[6] Univ Texas Austin, Inst Cell & Mol Biol, Austin, TX 78712 USA

来源：

METALLOMICS | 2010年 / 2卷 / 03期

关键词：

BRAIN DELIVERY; TOXICITY; IONS;

D O I：

10.1039/b916107d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Silver nanocrystals (Ag NCs) hold promising antibiotic and antiviral properties in biological systems. The biodistribution of silver nanostructures injected into animals in vivo is currently unknown, remaining as a fundamental issue for potential therapeutic applications. Here, we injected Ag NCs capped with bovine serum albumin (BSA) in live rats to elucidate their fate in several organs including liver, heart and brain. Very significant accumulations of nanoparticles were confirmed by inductively coupled plasma mass spectroscopy (ICPMS) and transmission electron microscopy (TEM) techniques on the liver and heart. In contrast, the brain tissue did not reveal evidence of particles content. Our results suggest that Ag+ permeated across the blood-brain barrier (BBB), and followed swift clearance from the organ.

引用

页码：204 / 210

页数：7

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