Downregulation of RAI14 inhibits the proliferation and invasion of breast cancer cells

被引：20

作者：

Gu, Ming ^{[1
]}

Zheng, Wenhui ^{[2
]}

Zhang, Mingdi ^{[3
]}

Dong, Xiaoshen ^{[1
]}

Zhao, Yan ^{[1
]}

Wang, Shuo ^{[1
]}

Jiang, Haiyang ^{[1
]}

Liu, Lu ^{[1
]}

Zheng, Xinyu ^{[1
,4
]}

机构：

[1] China Med Univ, Affiliated Hosp 1, Dept Breast Surg, 155 Nanjing North St, Shenyang 110001, Liaoning, Peoples R China

[2] China Med Univ, Shengjing Hosp, Dept Anesthesiol, Shenyang 110001, Liaoning, Peoples R China

[3] Fudan Univ, Obstet & Gynecol Hosp, Dept Breast Surg, Shanghai 200011, Peoples R China

[4] China Med Univ, Affiliated Hosp 1, Canc Inst, Lab 1, Shenyang 110001, Liaoning, Peoples R China

来源：

JOURNAL OF CANCER | 2019年 / 10卷 / 25期

关键词：

retinoic acid-induced 14; breast cancer; cell proliferation; migration; invasion; CYCLIN D1; EXPRESSION; PROGRESSION; NORPEG;

D O I：

10.7150/jca.34910

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Retinoic acid-induced 14 (RAI14) is involved in the development of different tumor types, however, its expression and biological function in breast cancer are yet unknown. In the current study, we demonstrated that RAI14 was highly expressed in breast cancer. The high expression of RAI14 is positively correlated with the malignant progression of breast cancer and suggests a worse prognosis. Further, we found that knockdown RAI14 inhibits the proliferation, migration and invasion of breast cancer cells by regulating cell cycle and EMT through Akt/Cyclin D1, MMP2, MMP9 and ZEB1/E-cadhrin/Vimentin pathway. These findings revealed a novel function for RAI14 in breast cancer progression and suggest that RAI14 may become a promising diagnostic and therapeutic target for breast cancer.

引用

页码：6341 / 6348

页数：8

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