Release of PLGA-encapsulated dexamethasone from microsphere loaded porous surfaces

被引：30

作者：

Dawes, G. J. S. ^{[1
]}

Fratila-Apachitei, L. E. ^{[1
]}

Necula, B. S. ^{[1
]}

Apachitei, I. ^{[1
]}

Witkamp, G. J. ^{[2
]}

Duszczyk, J. ^{[1
]}

机构：

[1] Delft Univ Technol, Dept Mat Sci & Engn, NL-2628 CD Delft, Netherlands

[2] Delft Univ Technol, Lab Proc Equipment, NL-2628 CA Delft, Netherlands

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2010年 / 21卷 / 01期

关键词：

IMPLANTABLE MEDICAL DEVICES; IN-VITRO; CONTROLLED DELIVERY; DRUG-DELIVERY; ELUTING STENT; NANOSPHERES; BIOCOMPATIBILITY; HYDROXYAPATITE; BIODEGRADATION; NANOPARTICLES;

D O I：

10.1007/s10856-009-3846-6

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The aim of the present study was to investigate the morphology and function of a drug eluting metallic porous surface produced by the immobilization of poly lactide-co-glycolide microspheres bearing dexamethasone onto plasma electrolytically oxidized Ti-6Al-7Nb medical alloy. Spheres of 20 mu m diameter were produced by an oil-in-water emulsion/solvent evaporation method and thermally immobilized onto titanium discs. The scanning electron microscopy investigations revealed that the size distribution and morphology of the attached spheres had not changed significantly. The drug release profiles following degradation in phosphate buffered saline for 1000 h showed that, upon immobilisation, the spheres maintained a sustained release, with a triphasic profile similar to the non-attached system. The only significant change was an increased release rate during the first 100 h. This difference was attributed to the effect of thermal attachment of the spheres to the surface.

引用

页码：215 / 221

页数：7