Target highlights in CASP13: Experimental target structures through the eyes of their authors

被引：9

作者：

Lepore, Rosalba ^{[1
]}

Kryshtafovych, Andriy ^{[2
]}

Alahuhta, Markus ^{[3
]}

Veraszto, Harshul A. ^{[4
]}

Bomble, Yannick J. ^{[3
]}

Bufton, Joshua C. ^{[5
,6
]}

Bullock, Alex N. ^{[5
]}

Caba, Cody ^{[7
]}

Cao, Hongnan ^{[8
,9
]}

Davies, Owen R. ^{[10
]}

Desfosses, Ambroise ^{[11
,12
]}

Dunne, Matthew ^{[13
]}

Fidelis, Krzysztof ^{[2
]}

Goulding, Celia W. ^{[14
]}

Gurusaran, Manickam ^{[10
]}

Gutsche, Irina ^{[12
]}

Harding, Christopher J. ^{[15
]}

Hartmann, Marcus D. ^{[4
]}

Hayes, Christopher S. ^{[16
]}

Joachimiak, Andrzej ^{[17
,18
]}

Leiman, Petr G. ^{[19
]}

Loppnau, Peter ^{[20
]}

Lovering, Andrew L. ^{[15
]}

Lunin, Vladimir V. ^{[3
]}

Michalska, Karolina ^{[17
]}

Mir-Sanchis, Ignacio ^{[18
,27
,28
]}

Mitra, Alok ^{[11
]}

Moult, John ^{[21
]}

Phillips, George N., Jr. ^{[8
,9
]}

Pinkas, Daniel M. ^{[5
]}

Rice, Phoebe A. ^{[18
]}

Tong, Yufeng ^{[7
,20
]}

Topf, Maya ^{[22
]}

Walton, Jonathan D. ^{[23
,24
]}

Schwede, Torsten ^{[25
,26
]}

机构：

[1] BSC CNS Barcelona Supercomp Ctr, Jordi Girona 29, Barcelona 08034, Spain

[2] Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA

[3] Natl Renewable Energy Lab, Biosci Ctr, Golden, CO USA

[4] Max Planck Inst Dev Biol, Dept Prot Evolut, Tubingen, Germany

[5] Univ Oxford, Nuffield Dept Med, Struct Genom Consortium, Oxford, England

[6] Univ Bristol, Sch Biochem, Bristol, Avon, England

[7] Univ Windsor, Dept Chem & Biochem, Windsor, ON, Canada

[8] Rice Univ, Dept Biosci, Houston, TX USA

[9] Univ Wisconsin, Great Lakes Bioenergy Res Ctr, Madison, WI USA

[10] Newcastle Univ, Inst Cell & Mol Biosci, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England

[11] Univ Auckland, Sch Biol Sci, Auckland, New Zealand

[12] Univ Grenoble Alpes, CNRS, CEA, Inst Biol Struct, Grenoble, France

[13] Inst Food Nutr & Hlth, Zurich, Switzerland

[14] Univ Calif Irvine, Dept Mol Biol & Biochem Pharmaceut Sci, Irvine, CA USA

[15] Univ Birmingham, Sch Biosci, Birmingham, W Midlands, England

[16] Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Biomol Sci & Engn Program, Santa Barbara, CA 93106 USA

[17] Midwest Ctr Struct Genom, Struct Biol Ctr, Biosci Div, Argonne, IL USA

[18] Univ Chicago, Dept Biochem & Mol Biol, 920 E 58Th St, Chicago, IL 60637 USA

[19] Univ Texas Med Branch, Dept Biochem & Mol Biol, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA

[20] Univ Toronto, Struct Genom Consortium, Toronto, ON, Canada

[21] Univ Maryland, Inst Biosci & Biotechnol Res, Dept Cell Biol & Mol Genet, Rockville, MD USA

[22] UCL, Inst Struct & Mol Biol, London, England

[23] Michigan State Univ, Great Lakes Bioenergy Res Ctr, E Lansing, MI 48824 USA

[24] Michigan State Univ, Dept Plant Biol, E Lansing, MI 48824 USA

[25] Biozentrum Univ Basel, Basel, Switzerland

[26] Biozentrum Univ Basel, Swiss Inst Bioinformat, Basel, Switzerland

[27] Umea Univ, Dept Med Biochem, Umea, Sweden

[28] Umea Univ, Wallenberg Ctr Mol Med, Umea, Sweden

来源：

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2019年 / 87卷 / 12期

基金：

英国惠康基金; 美国国家卫生研究院; 英国生物技术与生命科学研究理事会; 加拿大创新基金会;

关键词：

CASP; protein structure prediction; cryo-EM; X-ray crystallography; NATIVE GABA(B) RECEPTORS; ACYL-COA DEHYDROGENASES; COLI ADAPTIVE RESPONSE; GROWTH-INHIBITION CDI; SHIKIMATE PATHWAY; ELECTRON-TRANSFER; NUCLEAR-MEMBRANE; LIGASE RFWD3; DNA; TOXIN;

D O I：

10.1002/prot.25805

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The functional and biological significance of selected CASP13 targets are described by the authors of the structures. The structural biologists discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submitted to the CASP13 experiment.

引用

页码：1037 / 1057

页数：21

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