Increased CXCL8 (IL-8) expression in multiple sclerosis

被引：111
作者：
Lund, BT
Ashikian, N
Ta, HQ
Chakryan, Y
Manoukian, K
Groshen, S
Gilmore, W
Cheema, GS
Stohl, W
Burnett, ME
Ko, D
Kachuck, NJ
Weiner, LP
机构：
[1] Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USA
[2] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA
[3] Univ So Calif, Keck Sch Med, Dept Cell & Neurobiol, Los Angeles, CA 90033 USA
[4] Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
[5] Univ So Calif, Los Angeles Cty Med Ctr, Keck Sch Med, Dept Med,Div Rheumatol, Los Angeles, CA 90033 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 155卷 / 1-2期
关键词：
multiple sclerosis; inflammation; CXCL8; interferon-beta; 1a; monocytes;
D O I：
10.1016/j.jneuroim.2004.06.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Multiple Sclerosis (MS) is a chronic inflammatory disease of the CNS which is characterized by large mononuclear cell infiltration and significant demyelination. CXCL8 is a chemo-attractant for both neutrophils and monocytes and triggers their firm adhesion to endothelium. In this study, we demonstrate that serum CXCL8 and CXCL8 secretion from PBMCs are significantly higher in untreated MS patients compared to controls and are significantly reduced in MS patients receiving interferon-beta1a therapy. We suggest that CXCL8 may serve as a marker of monocyte activity in MS and may play a role in monocyte recruitment to the CNS. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：161 / 171
页数：11
相关论文
共 101 条
[81]   Expression profiling identifies responder and non-responder phenotypes to interferon-β in multiple sclerosis [J].
Stürzebecher, S ;
Wandinger, KP ;
Rosenwald, A ;
Sathyamoorthy, M ;
Tzou, A ;
Mattar, P ;
Frank, JA ;
Staudt, L ;
Martin, R ;
McFarland, HF .
BRAIN, 2003, 126 :1419-1429
[82]  
Taub D D, 1994, Ther Immunol, V1, P229
[83]   HUMAN T-CELL RESPONSE TO MYELIN BASIC-PROTEIN IN MULTIPLE-SCLEROSIS PATIENTS AND HEALTHY-SUBJECTS [J].
TOURNIERLASSERVE, E ;
HASHIM, GA ;
BACH, MA .
JOURNAL OF NEUROSCIENCE RESEARCH, 1988, 19 (01) :149-156
[84]   Chemokine receptors on infiltrating leucocytes in inflammatory pathologies of the central nervous system (CNS) [J].
Trebst, C ;
Staugaitis, SM ;
Tucky, B ;
Wei, T ;
Suzuki, K ;
Aldape, KD ;
Pardo, CA ;
Troncoso, J ;
Lassmann, H ;
Ransohoff, RM .
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2003, 29 (06) :584-595
[85]   PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM MULTIPLE-SCLEROSIS PATIENTS RECOGNIZE MYELIN PROTEOLIPID PROTEIN AND SELECTED PEPTIDES [J].
TROTTER, JL ;
HICKEY, WF ;
VANDERVEEN, RC ;
SULZE, L .
JOURNAL OF NEUROIMMUNOLOGY, 1991, 33 (01) :55-62
[86]   THE NEUTROPHIL-ACTIVATING PROTEINS INTERLEUKIN-8 AND BETA-THROMBOGLOBULIN - INVITRO AND INVIVO COMPARISON OF NH2-TERMINALLY PROCESSED FORMS [J].
VANDAMME, J ;
RAMPART, M ;
CONINGS, R ;
DECOCK, B ;
VANOSSELAAER, N ;
WILLEMS, J ;
BILLIAU, A .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (09) :2113-2118
[87]   A NOVEL, NH2-TERMINAL SEQUENCE CHARACTERIZED HUMAN MONOKINE POSSESSING NEUTROPHIL CHEMOTACTIC, SKIN-REACTIVE, AND GRANULOCYTOSIS-PROMOTING ACTIVITY [J].
VANDAMME, J ;
VANBEEUMEN, J ;
OPDENAKKER, G ;
BILLIAU, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (04) :1364-1376
[88]   Interferon-beta prevents cytokine-induced neutrophil infiltration and attenuates blood-brain barrier disruption [J].
Veldhuis, TB ;
Floris, T ;
van der Meide, PH ;
Vos, IMP ;
de Vries, HE ;
Dijkstra, TD ;
Bär, PR ;
Nicolay, K .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (09) :1060-1069
[89]   PURIFICATION AND AMINO-ACID SEQUENCING OF NAF, A NOVEL NEUTROPHIL-ACTIVATING FACTOR PRODUCED BY MONOCYTES [J].
WALZ, A ;
PEVERI, P ;
ASCHAUER, H ;
BAGGIOLINI, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 149 (02) :755-761
[90]   NEUROIMMUNOLOGY-I - IMMUNOREGULATION IN NEUROLOGICAL DISEASE [J].
WEINER, HL ;
HAUSER, SL .
ANNALS OF NEUROLOGY, 1982, 11 (05) :437-449
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