Increased CXCL8 (IL-8) expression in multiple sclerosis

被引：111

作者：

Lund, BT

Ashikian, N

Ta, HQ

Chakryan, Y

Manoukian, K

Groshen, S

Gilmore, W

Cheema, GS

Stohl, W

Burnett, ME

Ko, D

Kachuck, NJ

Weiner, LP

机构：

[1] Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USA

[2] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[3] Univ So Calif, Keck Sch Med, Dept Cell & Neurobiol, Los Angeles, CA 90033 USA

[4] Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA

[5] Univ So Calif, Los Angeles Cty Med Ctr, Keck Sch Med, Dept Med,Div Rheumatol, Los Angeles, CA 90033 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 155卷 / 1-2期

关键词：

multiple sclerosis; inflammation; CXCL8; interferon-beta; 1a; monocytes;

D O I：

10.1016/j.jneuroim.2004.06.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple Sclerosis (MS) is a chronic inflammatory disease of the CNS which is characterized by large mononuclear cell infiltration and significant demyelination. CXCL8 is a chemo-attractant for both neutrophils and monocytes and triggers their firm adhesion to endothelium. In this study, we demonstrate that serum CXCL8 and CXCL8 secretion from PBMCs are significantly higher in untreated MS patients compared to controls and are significantly reduced in MS patients receiving interferon-beta1a therapy. We suggest that CXCL8 may serve as a marker of monocyte activity in MS and may play a role in monocyte recruitment to the CNS. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：161 / 171

页数：11

共 101 条

[1] Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45 [J].