Remote Ischemic Conditioning: Evolution of the Concept, Mechanisms, and Clinical Application

被引：86
作者：
Saxena, Pankaj [2 ]
Newman, Mark A. J. [2 ]
Shehatha, Jaffar S. [2 ]
Redington, Andrew N. [3 ]
Konstantinov, Igor E. [1 ,2 ]
机构：
[1] Royal Childrens Hosp, Cardiac Surg Unit, Melbourne, Vic 3052, Australia
[2] Univ Western Australia, Dept Cardiothorac Surg, Sir Charles Gairdner Hosp, Perth, WA 6009, Australia
[3] Univ Toronto, Hosp Sick Children, Dept Cardiol, Toronto, ON M5G 1X8, Canada
来源：
JOURNAL OF CARDIAC SURGERY | 2010年 / 25卷 / 01期
关键词：
FACTOR-KAPPA-B; ACUTE MYOCARDIAL-INFARCTION; LOWER-LIMB ISCHEMIA; PRECONDITIONING PROTECTS; GENE-EXPRESSION; LATE-PHASE; CARDIOPULMONARY BYPASS; REPERFUSION INJURY; CARDIAC-SURGERY; DELAYED CARDIOPROTECTION;
D O I：
10.1111/j.1540-8191.2009.00820.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
P>Remote ischemic conditioning is a novel concept of protection against ischemia-reperfusion injury. Brief controlled episodes of intermittent ischemia of the arm or leg may confer a powerful systemic protection against prolonged ischemia in a distant organ. This conditioning phenomenon is clinically applicable and can be performed before-preconditioning, during-perconditioning, or after-postconditioning prolonged distant organ ischemia. The remote ischemic conditioning may have an immense impact on clinical practice in the near future. (J Card Surg 2010;25:127-134).
引用
收藏
页码：127 / 134
页数：8
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