Remote Ischemic Conditioning: Evolution of the Concept, Mechanisms, and Clinical Application

被引：86

作者：

Saxena, Pankaj ^{[2
]}

Newman, Mark A. J. ^{[2
]}

Shehatha, Jaffar S. ^{[2
]}

Redington, Andrew N. ^{[3
]}

Konstantinov, Igor E. ^{[1
,2
]}

机构：

[1] Royal Childrens Hosp, Cardiac Surg Unit, Melbourne, Vic 3052, Australia

[2] Univ Western Australia, Dept Cardiothorac Surg, Sir Charles Gairdner Hosp, Perth, WA 6009, Australia

[3] Univ Toronto, Hosp Sick Children, Dept Cardiol, Toronto, ON M5G 1X8, Canada

来源：

JOURNAL OF CARDIAC SURGERY | 2010年 / 25卷 / 01期

关键词：

FACTOR-KAPPA-B; ACUTE MYOCARDIAL-INFARCTION; LOWER-LIMB ISCHEMIA; PRECONDITIONING PROTECTS; GENE-EXPRESSION; LATE-PHASE; CARDIOPULMONARY BYPASS; REPERFUSION INJURY; CARDIAC-SURGERY; DELAYED CARDIOPROTECTION;

D O I：

10.1111/j.1540-8191.2009.00820.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>Remote ischemic conditioning is a novel concept of protection against ischemia-reperfusion injury. Brief controlled episodes of intermittent ischemia of the arm or leg may confer a powerful systemic protection against prolonged ischemia in a distant organ. This conditioning phenomenon is clinically applicable and can be performed before-preconditioning, during-perconditioning, or after-postconditioning prolonged distant organ ischemia. The remote ischemic conditioning may have an immense impact on clinical practice in the near future. (J Card Surg 2010;25:127-134).

引用

页码：127 / 134

页数：8

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