Fluorine & chirality: how to create a nonracemic stereogenic carbon-fluorine centre?

被引：217

作者：

Cahard, Dominique ^{[1
]}

Xu, Xiuhua

Couve-Bonnaire, Samuel

Pannecoucke, Xavier

机构：

[1] Univ Rouen, CNRS, COBRA, UMR 6014, F-76130 Mont St Aignan, France

来源：

CHEMICAL SOCIETY REVIEWS | 2010年 / 39卷 / 02期

关键词：

BETA-KETO-ESTERS; CATALYZED ALLYLATION REACTION; SILYL ENOL ETHERS; ENANTIOSELECTIVE SYNTHESIS; STREPTOMYCES-CATTLEYA; ALPHA-FLUOROKETONES; ELECTROPHILIC FLUORINATION; ASYMMETRIC HYDROGENATION; CINCHONA ALKALOIDS; ALDOL REACTIONS;

D O I：

10.1039/b909566g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantiopure organofluorine compounds are at the forefront of innovation in the field of fluorine chemistry. The significant progress in modern fluoroorganic chemistry parallels the tremendous achievements in organocatalysis and organometallic catalysis that have permitted the asymmetric synthesis of chiral chemicals featuring a fluorinated stereogenic carbon centre. This tutorial review provides an overview of the current state of the art in asymmetric construction of stereogenic carbon-fluorine centres, not only by direct fluorination, but also by asymmetric reaction of fluorinated substrates.

引用

页码：558 / 568

页数：11

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