Pomolic acid may overcome multidrug resistance mediated by overexpression of anti-apoptotic Bcl-2 proteins

被引：25

作者：

Fernandes, Janaina

Weinlich, Ricardo

Castilho, Rachel Oliveira

Amarante-Mendes, Gustavo Pessini

Gattass, Cerli Rocha ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Lab Imunoparasitol, Inst Biofis Carlos Chagas Filho, Ctr Ciencias Saude,Bloco G,Cidade Univ, BR-21949900 Rio De Janeiro, Brazil

[2] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, BR-05508900 Sao Paulo, Brazil

[3] Univ Sao Paulo, Millenium Inst, Inst Invest Immunol, BR-05508900 Sao Paulo, Brazil

[4] Univ Catolica Dom Bosco, BR-79117900 Campo Grande, MS, Brazil

来源：

CANCER LETTERS | 2007年 / 245卷 / 1-2期

基金：

巴西圣保罗研究基金会;

关键词：

pomolic acid; MDR; anti-apoptotic proteins; Bcl-2 and Bcl-xL; leukemia; apoptosis;

D O I：

10.1016/j.canlet.2006.01.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multidrug resistance (MDR) is multifactorial and may be mediated by overexpression of anti-apoptotic proteins. This paper investigated whether pomolic acid (PA) was able to overcome resistance mediated by overexpression of Bcl-2 or BcL-xL. The results obtained showed that overexpression of these proteins partially inhibited the PA-induced apoptosis, loss of mitochondrial membrane potential and caspase -3 and -9 activation observed in HL-60/neo. Since Bcl-2 transfected cell lines were shown to be quite resistant to a series of chemotherapeutic agents, the data presented call attention to the possible clinical significance of PA as an anti-MDR drug. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：315 / 320

页数：6

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