Direct synthesis of quinazolinones via the carbon-supported acid-catalyzed cascade reaction of isatoic anhydrides with amides and aldehydes

被引：6

作者：

Zhang, Xiangyu ^{[1
]}

Luo, Chujun ^{[1
]}

Chen, Xiaoyong ^{[1
]}

Ma, Weilin ^{[1
]}

Li, Bin ^{[1
]}

Lin, Zirui ^{[1
]}

Chen, Xiuwen ^{[1
]}

Li, Yibiao ^{[1
]}

Xie, Feng ^{[1
]}

机构：

[1] Wuyi Univ, Sch Chem & Environm Engn, Jiangmen 529020, Guangdong, Peoples R China

来源：

TETRAHEDRON LETTERS | 2021年 / 66卷

基金：

中国国家自然科学基金;

关键词：

Reusable acid; Cascade coupling; Quinazolinones; Hydrosilylation; Dihydroquinazolines;

D O I：

10.1016/j.tetlet.2021.152835

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel catalytic system is reported for the construction of quinazolinones via the carbon-supported acid-catalyzed cascade coupling of isatoic anhydrides with amides and aldehydes. Subsequent selective hydrosilylation of the quinazolinones using a hydrogen-transfer strategy was also explored to provide dihydroquinazolines with structural diversity. The developed methodology proceeds with a broad substrate scope, excellent functional group tolerance, and utilizes a reusable catalyst and air as a green oxidant. (C) 2021 Elsevier Ltd. All rights reserved.

引用

页数：5

共 47 条

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