A zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment

被引：43

作者：

Schorpp, M ^{[1
]}

Leicht, M ^{[1
]}

Nold, E ^{[1
]}

Hammerschmidt, M ^{[1
]}

Haas-Assenbaum, A ^{[1
]}

Wiest, W ^{[1
]}

Boehm, T ^{[1
]}

机构：

[1] Max Planck Inst Immunbiol, Dept Dev Immunol, D-79108 Freiburg, Germany

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 118卷 / 1-2期

关键词：

zebrafish orthologue; epithelial compartment; embryonic thymic rudiment; nude mouse;

D O I：

10.1016/S0925-4773(02)00241-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The cloning and characterization of the zebrafish orthologue of the mouse nude (Whn/Foxnl) gene, whnb are reported. A previously described Whn-like gene from zebrafish, now designated as whna, is shown to be the orthologue of the mouse Foxn4 gene. The whnb gene is specifically expressed in the thymic rudiment of zebrafish embryos at day 3 after fertilization, whereas the whna gene is expressed in eye and brain structures. whnb expression is maintained in cloche mutants, where endothelial and haematopoietic cell differentiation is defective, but absent in casanova mutants where endoderm formation is impaired. In adult thymi, whnb is expressed throughout cortical and medullary areas, whereas whna expression is observed in rare cell clusters only. Our results provide the first specific marker for the epithelial compartment of the zebrafish thymus. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：179 / 185

页数：7

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