Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies

被引：76

作者：

Manap, Aimi Syamima Abdul ^{[1
]}

Vijayabalan, Shantini ^{[2
]}

Madhavan, Priya ^{[3
]}

Chia, Yoke Yin ^{[1
]}

Arya, Aditya ^{[3
]}

Wong, Eng Hwa ^{[3
]}

Rizwan, Farzana ^{[3
]}

Bindal, Umesh ^{[3
]}

Koshy, Shajan ^{[3
]}

机构：

[1] Taylors Univ, Fac Hlth & Med Sci, Sch Biosci, Subang Jaya, Malaysia

[2] Taylors Univ, Fac Hlth & Med Sci, Sch Pharm, Subang Jaya, Malaysia

[3] Taylors Univ, Fac Hlth & Med Sci, Sch Med, 1 Jalan Taylors, Subang Jaya 47500, Selangor Darul, Malaysia

来源：

DRUG TARGET INSIGHTS | 2019年 / 13卷

关键词：

Alzheimer; aging; therapeutic plant; Bacopa monnieri; bacosides; DOUBLE-BLIND; BACOSIDE-A; OXIDATIVE STRESS; SPECIAL EXTRACT; CDRI; 08; CEREBRAL-CORTEX; BRAIN; BRAHMI; CYTOTOXICITY; NEURODEGENERATION;

D O I：

10.1177/1177392819866412

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Alzheimer disease is a neurodegenerative disease that is signified by cognitive decline, memory loss. and erratic behavior. Till date no cure for Alzheimer exists and the current Alzheimer medications have limited effectiveness. However. herbal medicines may slow down the disease's progression, which may hopefully reduce the number of cases in the years to come. Numerous studies have been done on characterizing the neuroprotective properties from plants belonging to Scrophulariaceae family, particularly Bacopa monnieri and its polyphenolic compounds known as bacosides. This review presents the findings on bacosides in therapeutic plants and their impact on Alzheimer disease pathology. These reports present data on the clinical, cellular activities, phytochemistry, and biological applications that may be used in new drug treatment for Alzheimer disease.

引用

页数：13

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