Cholesterol reduction following health screening in general practice

Objectives - To evaluate changes in plasma cholesterol following health screening and health discussions in general practice. Design - Randomised prospective population-base d study conducted over a period of 5 years. Setting - Primary care, all general practitioners (GPs) in a well-defined area. Subjects - A random sample of inhabitants aged 30-49 years in January 1991, registered with a local GP was invited to participate. The participants (1507 persons, or 75.4% of the 2000 invited) were randomly allocated to two intervention groups and a control group. Main outcome measures - Plasma cholesterol, percentage of subjects with plasma cholesterol higher than 7 mmol/l. Results - After 5 years of intervention, plasma cholesterol in the whole population was significantly lower in the intervention groups compared to the control group. The decrease was most pronounced (0.5 mmol/l) in subjects at high cardiovascular risk. The percentage of high-risk individuals with a cholesterol level higher than 7 mmol/l was significantly lower in the intervention groups compared to the control group (9.8% vs 6.2%, p = 0.04), corresponding to a 37% reduction. Conclusions - The study shows that the health checks had a measurable impact on plasma cholesterol levels, the most pronounced effect is seen among individuals at high cardiovascular risk.