Cholesterol in β-cell Dysfunction: The Emerging Connection Between HDL Cholesterol and Type 2 Diabetes

被引：54

作者：

Brunham, Liam R. ^{[1
]}

Kruit, Janine K. ^{[1
]}

Hayden, Michael R. ^{[1
]}

Verchere, C. Bruce ^{[1
]}

机构：

[1] Child & Family Res Inst, Vancouver, BC V5Z 4H4, Canada

来源：

CURRENT DIABETES REPORTS | 2010年 / 10卷 / 01期

基金：

加拿大健康研究院;

关键词：

Islet; Beta cell; Cholesterol; HDL; CASSETTE TRANSPORTER A1; LOW-DENSITY-LIPOPROTEIN; INSULIN-SECRETION; MEXICAN POPULATION; TANGIER-DISEASE; TRANSGENIC MICE; ABCA1; VARIANTS; R230C VARIANT; FOAM CELLS; APOA-I;

D O I：

10.1007/s11892-009-0090-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

beta-cell dysfunction is a critical step in the pathogenesis of type 2 diabetes. The mechanisms responsible for beta-cell death and dysfunction remain incompletely understood, but include glucolipotoxicity, the deleterious metabolic milieu created by high plasma concentrations of glucose and lipid species. Recently, an important role has emerged for cholesterol in this process. In this article, we review recent advances in our understanding of the role of ABCA1 and cholesterol metabolism in beta-cell function, with particular attention to insights gained from human studies.

引用

页码：55 / 60

页数：6

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