The mechanisms of kinesin motor motility: lessons from the monomeric motor KIF1A

被引:92
作者
Hirokawa, Nobutaka [1 ]
Nitta, Ryo [1 ]
Okada, Yasushi [1 ]
机构
[1] Univ Tokyo, Grad Sch Med, Dept Cell Biol & Anat, Bunkyo Ku, Tokyo, Japan
关键词
HAND-OVER-HAND; MICROTUBULE-BASED MOTILITY; STIMULATED ATP HYDROLYSIS; SUPERFAMILY PROTEIN KIF1A; CRYSTAL-STRUCTURE; AXONAL-TRANSPORT; INTRACELLULAR-TRANSPORT; CATALYTIC CORE; NECK-LINKER; K-LOOP;
D O I
10.1038/nrm2807
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Most kinesins move processively along microtubules by using energy derived from ATP hydrolysis. Almost all of the intermediate structures of this ATPase reaction cycle have been solved for the monomeric kinesin 3 family motor KIF1A. Based on this structural information, we propose a common mechanism of kinesin motility, focusing on the regulation of kinesin motility through their interaction with microtubules and by their 'neck-linker' region, which connects their motor domain to cargo and kinesin partner heads.
引用
收藏
页码:877 / 884
页数:9
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