Highly enantioselective michael addition of aromatic ketones to nitroolefins promoted by chiral bifunctional primary amine-thiourea catalysts based on saccharides

被引：232

作者：

Liu, Kun ^{[1
]}

Cui, Han-Feng ^{[1
]}

Nie, Jing ^{[1
]}

Dong, Ke-Yan ^{[1
]}

Li, Xiao-Juan ^{[1
]}

Ma, Jun-An ^{[1
]}

机构：

[1] Tianjin Univ, Dept Chem, Tianjin 300072, Peoples R China

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 05期

关键词：

D O I：

10.1021/ol0701666

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new class of thiourea catalysts have been developed which integrate saccharide and primary amine moieties into one small organic molecule. These simple catalysts are shown to be highly enantioselective for direct Michael addition of aromatic ketones to a range of nitroolefins (up to 98% ee).

引用

页码：923 / 925

页数：3

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