Identification of lncRNA-miRNA-mRNA regulatory network associated with epithelial ovarian cancer cisplatin-resistant

被引：50
作者：
Zhao, Xin [1 ]
Tang, Dong-Yang [2 ]
Zuo, Xu [1 ]
Zhang, Tian-Dong [1 ]
Wang, Cheng [3 ]
机构：
[1] Xinxiang Cent Hosp, Dept Pharm, Xinxiang 453000, Henan, Peoples R China
[2] Henan Inst Sci & Technol, Dept Expt Management Ctr, Xinxiang 453003, Henan, Peoples R China
[3] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 11期
关键词：
cisplatin-resistant; epithelial ovarian cancer; lncRNA; miRNA; mRNA; NONCODING RNA; CHEMORESISTANCE; PERSPECTIVES; OXALIPLATIN; METASTASIS; BIOGENESIS; TARGET;
D O I：
10.1002/jcp.28587
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
To construct a long noncoding RNA (lncRNA)-microRNA (miRNA)-messenger RNA (mRNA) regulatory network related to epithelial ovarian cancer (EOC) cisplatin-resistant, differentially expressed genes (DEGs), differentially expressed lncRNAs (DELs), and differentially expressed miRNAs (DEMs) between MDAH and TOV-112D cells lines were identified. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were conducted to analyze the biological functions of DEGs. Downstream mRNAs or upstream lncRNAs for miRNAs were analyzed at miRTarBase 7.0 or DIANA-LncBase V2, respectively. A total of 485 significant DEGs, 85 DELs, and 5 DEMs were identified. Protein-protein interaction (PPI) network of DEGs contrains 81 nodes and 141 edges was constructed, and 25 hub genes related to EOC cisplatin-resistant were identified. Subsequently, a lncRNA-miRNA-mRNA regulatory network contains 4 lncRNAs, 4 miRNAs, and 35 mRNAs was established. Taken together, our study provided evidence concerning the alteration genes involved in EOC cisplatin-resistant, which will help to unravel the mechanisms underlying drug resistant.
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收藏
页码：19886 / 19894
页数：9
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