Coronavirus Infections in the Nervous System of Children: A Scoping Review Making the Case for Long-Term Neurodevelopmental Surveillance

被引:35
作者
Singer, Timothy G. [1 ]
Evankovich, Karen D. [2 ,3 ]
Fisher, Kristen [4 ]
Demmler-Harrison, Gail J. [5 ]
Risen, Sarah R. [4 ]
机构
[1] Texas Childrens Hosp, Baylor Coll Med, Global Child Hlth Residency, Houston, TX 77030 USA
[2] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Sect Psychol, Houston, TX 77030 USA
[3] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Sect Neurol, Houston, TX 77030 USA
[4] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Sect Neurol & Dev Neurosci, Houston, TX 77030 USA
[5] Texas Childrens Hosp, Baylor Coll Med, Pediat Infect Dis, Houston, TX 77030 USA
关键词
Pediatric; Coronavirus; SARS-CoV-2; Neurodevelopmental outcomes; Multisystem inflammatory syndrome in children; COVID-19; Encephalitis; MULTISYSTEM INFLAMMATORY SYNDROME; ACUTE FLACCID MYELITIS; RESPIRATORY-INFECTIONS; MIS-C; OUTCOMES; ENCEPHALITIS; COVID-19; INVOLVEMENT; DISEASE; LESIONS;
D O I
10.1016/j.pediatrneurol.2021.01.007
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: The objective of this study was to describe the case literature of human coronavirus infections in the nervous system of children, including from SARS-CoV-2, and to provide guidance to pediatric providers for managing the potential long-term effects on neurodevelopment of human coronavirus infections in the nervous system. Methods: Using a structured strategy, the PubMed and Ovid:Embase databases were queried for articles about the clinical presentation and pathophysiology of coronavirus infections in the nervous system of children and young adults, aged 0 to 24 years. Results: Of 2302 articles reviewed, 31 described SARS-CoV-2 infections in the nervous system of children and 21 described other human coronaviruses: HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1, MERSCoV, SARS-CoV-1. Excepting MERS-CoV, we found cases of neurological disease in children from each human coronavirus. Children with non-SARS-CoV-2 infections have suffered acute flaccid paralysis, acute disseminated encephalomyelitis, encephalitis, and seizures. In addition, cases of ischemic, hemorrhagic, and microvascular strokes have occurred in children with SARS-CoV-2. Patients with multisystem inflammatory syndrome in children have suffered encephalitis, stroke, pseudotumor cerebri syndrome, and cytotoxic lesions of deep brain structures. Despite these reports, few articles evaluated the impact of human coronavirus infections on long-term neurodevelopmental domains including cognitive, language, academic, motor, and psychosocial outcomes. Conclusions: Neurological manifestations of human coronavirus infections can cause severe disease in children. The case literature suggests a critical gap in knowledge of the long-term effects on child neurodevelopment of these infections. As the current SARS-CoV-2 pandemic continues, this gap must be filled to facilitate optimal outcomes in recovering children. (C) 2021 Elsevier Inc. All rights reserved.
引用
收藏
页码:47 / 63
页数:17
相关论文
共 78 条
[1]   Encephalopathy and bilateral thalamic lesions in a child with MIS-C associated with COVID-19 [J].
Abel, Dori ;
Shen, Min Ye ;
Abid, Zaynah ;
Hennigan, Claire ;
Boneparth, Alexis ;
Miller, Emily Happy ;
Uhlemann, Anne-Catrin ;
McBrian, Danielle K. ;
Thakur, Kiran ;
Silver, Wendy ;
Bain, Jennifer M. .
NEUROLOGY, 2020, 95 (16) :745-748
[2]   Pediatric transverse myelitis [J].
Absoud, Michael ;
Greenberg, Benjamin M. ;
Lim, Ming ;
Lotze, Tim ;
Thomas, Terrence ;
Deiva, Kumaran .
NEUROLOGY, 2016, 87 (09) :S46-S52
[3]   Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature [J].
Algahtani, Hussein ;
Subahi, Ahmad ;
Shirah, Bader .
CASE REPORTS IN NEUROLOGICAL MEDICINE, 2016, 2016
[4]   Trajectories of brain development: point of vulnerability or window of opportunity? [J].
Andersen, SL .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2003, 27 (1-2) :3-18
[5]   SARS-CoV-2 Encephalitis in a 20-year old Healthy Female [J].
Babar, Aneeqa ;
Lewandowski, Ula ;
Capin, Ivana ;
Khariton, Megan ;
Venkataraman, Akila ;
Okolo, Nwanneka ;
Sharma, Dolly .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2020, 39 (10) :E320-E321
[6]   A pragmatic cluster randomised controlled trial of a tailored intervention to improve the initial management of suspected encephalitis [J].
Backman, Ruth ;
Foy, Robbie ;
Diggle, Peter J. ;
Kneen, Rachel ;
Easton, Ave ;
Defres, Sylviane ;
McGill, Fiona ;
Michael, Benedict Daniel ;
Solomon, Tom .
PLOS ONE, 2018, 13 (12)
[7]  
Barmore J., 2020, DETROIT NEWS
[8]   Childhood Epilepsy, Febrile Seizures, and Subsequent Risk of ADHD [J].
Bertelsen, Elin Naes ;
Larsen, Janne Tidselbak ;
Petersen, Liselotte ;
Christensen, Jakob ;
Dalsgaard, Soren .
PEDIATRICS, 2016, 138 (02)
[9]   Parechovirus Encephalitis and Neurodevelopmental Outcomes [J].
Britton, Philip N. ;
Dale, Russell C. ;
Nissen, Michael D. ;
Crawford, Nigel ;
Elliott, Elizabeth ;
Macartney, Kristine ;
Khandaker, Gulam ;
Booy, Robert ;
Jones, Cheryl A. .
PEDIATRICS, 2016, 137 (02)
[10]   Long-Term Neuropsychological Outcomes of Childhood Onset Acute Disseminated Encephalomyelitis (ADEM): a Meta-Analysis [J].
Burton, Karen L. O. ;
Williams, Tracey A. ;
Catchpoole, Sarah E. ;
Brunsdon, Ruth K. .
NEUROPSYCHOLOGY REVIEW, 2017, 27 (02) :124-133