Clinical relevance of insulin-like growth factor-1 to cardiovascular risk markers

被引:6
作者
Harada, Ko [1 ]
Hanayama, Yoshihisa [1 ]
Obika, Mikako [1 ]
Itoshima, Koichi [2 ]
Okada, Ken [2 ]
Otsuka, Fumio [1 ,2 ]
机构
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Med, Okayama, Japan
[2] Okayama Univ Hosp, Dept Lab Med, Okayama, Japan
关键词
Insulin-like growth factor-1; somatopause; anemia; inflammatory markers; fibrin-related markers; IGF-I; ASSOCIATION; HORMONE; ERYTHROPOIESIS; ENHANCEMENT; EXPRESSION; ANEMIA; COLONY; ADULTS;
D O I
10.1080/13685538.2019.1657083
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Insulin-like growth factor-1 (IGF-1) is an anabolic hormone, the levels of which decline with age. The present study aimed to determine the impact of age-related declines in serum IGF-1 levels on various physiological processes. Design: We retrospectively reviewed the medical records of patients whose serum IGF-1 levels were estimated in our department, and assessed the relationships between serum IGF-1 levels and various physiological parameters. Results: A total of 427 patients with a mean (+/- standard deviation) age of 52.8 (+/- 17.1) years were included in the analysis. The levels of serum IGF-1 showed significant positive correlation with those of hemoglobin and hematocrit, and negative correlation with the presence of inflammatory and fibrin-related markers including C-reactive protein (CRP) and procalcitonin (PCT), and D-dimer and fibrin degradation products (FDP). These tendencies persisted after exclusion of patients with pituitary disease. Conclusions: In this study population of diverse diseases and backgrounds, a decline in serum IGF-1 levels with age was associated with an increase in inflammatory and fibrin-related markers. This may explain the correlation between low serum IGF-1 levels and an increased risk of cardiovascular events. Our findings suggest that serum IGF-1 is a clinically relevant marker of cardiovascular risk, particularly in males.
引用
收藏
页码:1030 / 1038
页数:9
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