Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis

被引：27

作者：

Routhu, Nanda Kishore ^{[1
]}

Byrareddy, Siddappa N. ^{[1
,2
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68198 USA

[2] Univ Nebraska Med Ctr, Dept Biochem & Mol Biol, Omaha, NE 68198 USA

来源：

JOURNAL OF NEUROIMMUNE PHARMACOLOGY | 2017年 / 12卷 / 02期

关键词：

Host-virus interaction; Zika virus; Virus glycosylation; Immunity; Neuropathogenesis; ANTIBODY-DEPENDENT ENHANCEMENT; DENGUE VIRUS; WEST-NILE; NONSTRUCTURAL PROTEINS; NEURAL PROGENITORS; CRYSTAL-STRUCTURE; RNA-POLYMERASE; YELLOW-FEVER; CEREBRAL ORGANOIDS; COMPLEX-FORMATION;

D O I：

10.1007/s11481-017-9736-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Zika virus (ZIKV) is a newly emerging pathogen that has resulted in a worldwide epidemic. It primarily spreads either through infected Aedes aegypti or Aedes albopictus mosquitos leading to severe neurological disorders such as microcephaly and Guillain-Barr, syndrome in susceptible individuals. The mode of ZIKV entry into specific cell types such as: epidermal keratinocytes, fibroblasts, immature dendritic cells (iDCs), and stem-cell-derived human neural progenitors has been determined through its major surface envelope glycoprotein. It has been known that oligosaccharides that are covalently linked to viral envelope proteins are crucial in defining host-virus interactions. However, the role of sugars/glycans in exploiting host-immune mechanisms and aiding receptor-mediated virus entry is not well defined. Therefore, this review focuses on host-pathogen interactions to better understand ZIKV pathogenesis.

引用

页码：219 / 232

页数：14

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