Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis

被引：27
作者：
Routhu, Nanda Kishore [1 ]
Byrareddy, Siddappa N. [1 ,2 ]
机构：
[1] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68198 USA
[2] Univ Nebraska Med Ctr, Dept Biochem & Mol Biol, Omaha, NE 68198 USA
来源：
JOURNAL OF NEUROIMMUNE PHARMACOLOGY | 2017年 / 12卷 / 02期
关键词：
Host-virus interaction; Zika virus; Virus glycosylation; Immunity; Neuropathogenesis; ANTIBODY-DEPENDENT ENHANCEMENT; DENGUE VIRUS; WEST-NILE; NONSTRUCTURAL PROTEINS; NEURAL PROGENITORS; CRYSTAL-STRUCTURE; RNA-POLYMERASE; YELLOW-FEVER; CEREBRAL ORGANOIDS; COMPLEX-FORMATION;
D O I：
10.1007/s11481-017-9736-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The Zika virus (ZIKV) is a newly emerging pathogen that has resulted in a worldwide epidemic. It primarily spreads either through infected Aedes aegypti or Aedes albopictus mosquitos leading to severe neurological disorders such as microcephaly and Guillain-Barr, syndrome in susceptible individuals. The mode of ZIKV entry into specific cell types such as: epidermal keratinocytes, fibroblasts, immature dendritic cells (iDCs), and stem-cell-derived human neural progenitors has been determined through its major surface envelope glycoprotein. It has been known that oligosaccharides that are covalently linked to viral envelope proteins are crucial in defining host-virus interactions. However, the role of sugars/glycans in exploiting host-immune mechanisms and aiding receptor-mediated virus entry is not well defined. Therefore, this review focuses on host-pathogen interactions to better understand ZIKV pathogenesis.
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收藏
页码：219 / 232
页数：14
相关论文
共 131 条
[1]   New 5-Year Targets Announced for Health Care-Associated Infections [J].
Abbasi, Jennifer .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 316 (24) :2588-2588
[2]   Zika virus: a new pandemic threat [J].
Al-Qahtani, Ahmed A. ;
Nazir, Nyla ;
Al-Anazi, Mashael R. ;
Rubino, Salvatore ;
Al-Ahdal, Mohammed N. .
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2016, 10 (03) :201-207
[3]   The secreted form of dengue virus nonstructural protein NS1 is endocytosed by hepatocytes and accumulates in late endosomes: Implications for viral infectivity [J].
Alcon-LePoder, S ;
Drouet, MT ;
Roux, P ;
Frenkiel, MP ;
Arborio, M ;
Durand-Schneider, AM ;
Maurice, M ;
Le Blanc, I ;
Gruenberg, J ;
Flamand, M .
JOURNAL OF VIROLOGY, 2005, 79 (17) :11403-11411
[4]   Intracerebral infection with dengue-3 virus induces meningoencephalitis and behavioral changes that precede lethality in mice [J].
Amaral, Debora C. G. ;
Rachid, Milene A. ;
Vilela, Marcia C. ;
Campos, Roberta D. L. ;
Ferreira, Gustavo P. ;
Rodrigues, David H. ;
Lacerda-Queiroz, Norinne ;
Miranda, Aline S. ;
Costa, Vivian V. ;
Campos, Marco A. ;
Kroon, Erna G. ;
Teixeira, Mauro M. ;
Teixeira, Antonio L. .
JOURNAL OF NEUROINFLAMMATION, 2011, 8
[5]  
[Anonymous], 2016, B WORLD HEALTH ORGAN, V94, P562, DOI 10.2471/BLT.16.020816
[6]  
[Anonymous], GENOME ANNOUNC
[7]   Zika virus-associated neurological disorders: a review [J].
Araujo, Abelardo Q. C. ;
Silva, Marcus Tulius T. ;
Araujo, Alexandra P. Q. C. .
BRAIN, 2016, 139 :2122-2130
[8]   Guillain-Barre syndrome associated with the Zika virus outbreak in Brazil [J].
Araujo, Lucas Masiero ;
Brito Ferreira, Maria Lucia ;
Nascimento, Osvaldo J. M. .
ARQUIVOS DE NEURO-PSIQUIATRIA, 2016, 74 (03) :253-255
[9]   Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection [J].
Bayer, Avraham ;
Lennemann, Nicholas J. ;
Ouyang, Yingshi ;
Bramley, John C. ;
Morosky, Stefanie ;
De Azeved Marques, Ernesto Torres, Jr. ;
Cherry, Sara ;
Sadovsky, Yoel ;
Coyne, Carolyn B. .
CELL HOST & MICROBE, 2016, 19 (05) :705-712
[10]   Zika Virus Infection Induces Cranial Neural Crest Cells to Produce Cytokines at Levels Detrimental for Neurogenesis [J].
Bayless, Nicholas L. ;
Greenberg, Rachel S. ;
Swigut, Tomek ;
Wysocka, Joanna ;
Blish, Catherine A. .
CELL HOST & MICROBE, 2016, 20 (04) :423-428
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