Highly enantioselective alkynylation of α-keto ester:: An efficient method for constructing a chiral tertiary carbon center

被引：189

作者：

Jiang, B ^{[1
]}

Chen, ZL ^{[1
]}

Tang, XX ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 20期

关键词：

D O I：

10.1021/ol026544i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The asymmetric addition of terminal alkynes to a-keto ester was carried out using a catalytic amount of (11 S,2S)-3-(tert-butyldimethylsilyloxyl)2-N,N-(dimethylamino)-l-(p-nitrophenyl)-propane-1-ol in the presence of Zn(OTf)(2) to give the corresponding tertiary propargylic alcohols in high yields with up to 94% ee. N-Methylephedrine and Zn(OSO2CHF2)(2) were also examined in this reaction.

引用

页码：3451 / 3453

页数：3

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