Toll-like receptors as targets for inflammation, development and repair in the central nervous system

被引：0

作者：

van Noort, Johannes M. ^{[1
]}

机构：

[1] TNO Qual Life, Dept Biosci, NL-2301 CE Leiden, Netherlands

来源：

CURRENT OPINION IN INVESTIGATIONAL DRUGS | 2007年 / 8卷 / 01期

关键词：

astrocyte; CNS; inflammation; microglia; tissue repair; toll-like receptor;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Toll-like receptors (TLRs) that play key roles in inflammation are also widely expressed in the CNS. While they are well known to activate inflammatory responses to microbial products, TLRs fulfill additional roles in the absence of infection. Emerging evidence suggests that several TLRs play a role in CNS development during fetal life and in repair during adult life. This review discusses the available data on the expression and function of individual TLR family members in the CNS and clarifies why TLRs deserve close scrutiny as a novel group of therapeutic targets for CNS disorders.

引用

页码：60 / 65

页数：6

共 64 条

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