A High Dose of Intravenous Immunoglobulin Increases CD94 Expression on Natural Killer Cells in Women with Recurrent Spontaneous Abortion

被引：25

作者：

Shimada, Shigeki ^{[2
]}

Takeda, Masamitsu ^{[2
]}

Nishihira, Jun ^{[3
]}

Kaneuchi, Masanori ^{[2
]}

Sakuragi, Noriaki ^{[2
]}

Minakami, Hisanori ^{[2
]}

Yamada, Hideto ^{[1
]}

机构：

[1] Kobe Univ, Dept Obstet & Gynecol, Grad Sch Med, Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Hokkaido Univ, Grad Sch Med, Dept Obstet & Gynecol, Sapporo, Hokkaido, Japan

[3] Hokkaido Informat Univ, Dept Med Management & Informat, Ebetsu, Hokkaido, Japan

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2009年 / 62卷 / 05期

关键词：

CD94; immunoglobulin; natural killer cell; IDIOPATHIC THROMBOCYTOPENIC PURPURA; NKT CELLS; PERIPHERAL-BLOOD; PREGNANCY; MISCARRIAGE; PREVENTION; MOLECULE; RECEPTOR; THERAPY;

D O I：

10.1111/j.1600-0897.2009.00739.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Problem A high dose of intravenous immunoglobulin (HIVIg) therapy is effective in various diseases such as autoimmune diseases, and also is expected to have efficacy in recurrent spontaneous abortion (RSA). The aim of this study was to understand immunological mechanisms of this therapy. Method of study By flowcytometric analyses, we examined phenotypic changes of a variety of immunological cells including natural killer (NK) cells, cytotoxic T cells, regulatory T cells and macrophages in peripheral blood of RSA women with HIVIg therapy (n = 8). Results Expression percentages of inhibitory CD94 on NK cells significantly (P = 0.01) increased after the therapy (58.8 +/- 21.4% versus 71.0 +/- 17.6%). Conclusion Mechanisms of possible efficacy of HIVIg therapy for RSA may include enhancement of CD94 expression and subsequent suppression of NK cell cytotoxicity.

引用

页码：301 / 307

页数：7

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