Interaction of Afobazole with σ1-Receptors

被引：20

作者：

Seredenin, S. B. ^{[1
]}

Antipova, T. A. ^{[1
]}

Voronin, M. V. ^{[1
]}

Kurchashova, S. Yu. ^{[2
]}

Kuimov, A. N. ^{[2
]}

机构：

[1] Russian Acad Med Sci, VV Zakusov Inst Pharmacol, Moscow 109801, Russia

[2] Moscow MV Lomonosov State Univ, AN Belozerskii Inst Physicochem Biol, Moscow 117234, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2009年 / 148卷 / 01期

关键词：

afobazole; sigma(1)-receptor; radioligand binding; receptor translocation; SIGMA(1) BINDING-SITES; RECEPTOR; DRUGS;

D O I：

10.1007/s10517-009-0624-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In vitro radioligand assay revealed interaction of afobazole with sigma(1)-receptors (Ki=5.9 x 10(-6) M). Translocation of sigma(1)-receptors from the endoplasmic reticulum to the outer membrane was demonstrated by confocal microscopy. Experiments were performed on the model of HT-22 immortalized hippocampal cells after incubation with afobazole in a concentration of 10(-8) M.

引用

页码：42 / 44

页数：3

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