Mycobacterium bovis BCG-based vaccines against tuberculosis:: novel developments

被引：33
作者：
Dietrich, G
Viret, JF
Hess, J
机构：
[1] Berna Biotech Ltd, Bacterial Vaccine Res, CH-3018 Bern, Switzerland
[2] November AG, Erlangen, Germany
来源：
VACCINE | 2003年 / 21卷 / 7-8期
关键词：
Mycobacterium bovis; BCG; tuberculosis;
D O I：
10.1016/S0264-410X(02)00577-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mycobacterium bovis Bacille Calmette-Guerin (BCG) is one of the most widely used vaccines. Modern techniques in genome manipulation allow the construction of recombinant (r)-BCG strains that can be employed as highly immunogenic vaccines against tuberculosis (TB) with an enhanced safety profile. In addition, the development of novel procedures to cultivate BCG will allow the large-scale production of future BCG-based vaccines. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：667 / 670
页数：4
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