Biofunctional magnetic nanoparticles as contrast agents for magnetic resonance imaging of pancreas cancer

被引：5

作者：

Huang, Mingming ^{[1
]}

Qiao, Zhongwei ^{[2
]}

Miao, Fei ^{[2
]}

Jia, Nengqin ^{[1
]}

Shen, Hebai ^{[1
]}

机构：

[1] Shanghai Normal Univ, Life & Environm Sci Coll, Shanghai 200234, Peoples R China

[2] Ruijin Hosp, Dept Radiol, Shanghai 200025, Peoples R China

来源：

MICROCHIMICA ACTA | 2009年 / 167卷 / 1-2期

关键词：

Dextran-coated magnetic nanoparticles; CA19-9 monoclonal antibody; Pancreas cancer cells; Animal model; Contrast agents; Magnetic resonance imaging; IRON-OXIDE NANOPARTICLES; SUPERPARAMAGNETIC NANOPARTICLES; PHYSICOCHEMICAL CHARACTERISTICS; CHEMICAL-PROPERTIES; DRUG-DELIVERY; MR; NANOCRYSTALS; PARTICLES; STABILITY; FLUIDS;

D O I：

10.1007/s00604-009-0210-y

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We report on the fabrication and characterization of biofunctional magnetic nanoparticles as contrast agents for magnetic resonance imaging. The anti-cancer antigen 19-9 monoclonal antibody (a cancer-targeting antibody) was conjugated onto the magnetic contrast agents in an effort to detect pancreatic tumor. The structure, size, morphology and magnetic property of the biofunctional magnetic nanoparticles are characterized systematically by means of transmission electron microscopy and X-ray diffractometry. Furthermore, the interaction between the nanoparticles and pancreas cancers cells are investigated by atomic force microscope and transmission electron microscopy. Magnetic resonance imaging demonstrates that the conjugated nanoparticles can effectively target cancer cells both in vitro and in vivo, suggesting that they potentially can be used as contrast agents for magnetic resonance imaging of pancreas cancer.

引用

页码：27 / 34

页数：8

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