Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility

被引：41

作者：

Bae, Mihyun H. ^{[1
]}

Bissonette, Gregory B. ^{[1
,2
]}

Mars, Wendy M. ^{[3
]}

Michalopoulos, George K. ^{[3
]}

Achim, Cristian L. ^{[4
]}

Depireux, Didier A. ^{[5
]}

Powell, Elizabeth M. ^{[1
,2
,6
]}

机构：

[1] Univ Maryland, Sch Med, Dept Anat & Neurobiol, Baltimore, MD 21201 USA

[2] Univ Maryland, Program Neurosci, Baltimore, MD 21201 USA

[3] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15231 USA

[4] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[5] Univ Maryland, Syst Res Inst, College Pk, MD 20742 USA

[6] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA

来源：

EXPERIMENTAL NEUROLOGY | 2010年 / 221卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Epilepsy; Autism; HGF/SF; Met; Urokinase; GABA; Interneuron; Seizure; Parvalbumin; EEG; PLASMINOGEN-ACTIVATOR RECEPTOR; AUTISM SPECTRUM DISORDER; UROKINASE RECEPTOR; CEREBRAL-CORTEX; NEURON DEVELOPMENT; TYROSINE KINASE; INBRED STRAINS; KNOCKOUT MICE; C-MET; EXPRESSION;

D O I：

10.1016/j.expneurol.2009.10.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Disrupted ontogeny of forebrain inhibitory interneurons leads to neurological disorders, including epilepsy. Adult mice lacking the Urokinase plasminogen activator receptor (Plaur) have decreased numbers of neocortical GABAergic interneurons and spontaneous seizures, attributed to a reduction of hepatocyte growth factor/scatter factor (HGF/SF). We report that by increasing endogenous HGF/SF concentration in the postnatal Plaur null mouse brain maintains the interneuron populations in the adult, reverses the seizure behavior and stabilizes the spontaneous electroencephalogram activity. The perinatal intervention provides a pathway to reverse potential birth defects and ameliorate seizures in the adult. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：129 / 135

页数：7

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