CREM: A master-switch regulating the balance between differentiation and apoptosis in male germ cells

被引:0
作者
Sassone-Corsi, P [1 ]
机构
[1] CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Strasbourg, France
关键词
CREM; transcription factor; apoptosis; knock-out mice;
D O I
10.1002/(SICI)1098-2795(200006)56:2+<228::AID-MRD2>3.0.CO;2-B
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cyclic AMP-responsive element modulator (CREM) is a transcription factor highly expressed in the post-meiotic germ cells of the testis. its pivotal role is to regulate the expression of several germ cell-specific genes, a crucial function as demonstrated by the severe phenotype of mice whose CREM gene was mutated by homologous recombination. CREM-deficient male animals are sterile and display a ten-fold increase in the apoptosis of germ cells. Recent results have shown that CREM needs a tissue-specific co-activator, ACT (activator of CREM in testis) to elicit its regulatory function in testis. (C) 2000 Wiley-Liss, Inc.
引用
收藏
页码:228 / 229
页数:2
相关论文
共 10 条
[1]  
CHRESTA CM, 1996, NAT MED, V2, P744
[2]   CBP-independent activation of CREM and CREB by the LIM-only protein ACT [J].
Fimia, GM ;
De Cesare, D ;
Sassone-Corsi, P .
NATURE, 1999, 398 (6723) :165-169
[3]   DEVELOPMENTAL SWITCH OF CREM - FUNCTION DURING SPERMATOGENESIS - FROM ANTAGONIST TO ACTIVATOR [J].
FOULKES, NS ;
MELLSTROM, B ;
BENUSIGLIO, E ;
SASSONECORSI, P .
NATURE, 1992, 355 (6355) :80-84
[4]   PITUITARY-HORMONE FSH DIRECTS THE CREM FUNCTIONAL SWITCH DURING SPERMATOGENESIS [J].
FOULKES, NS ;
SCHLOTTER, F ;
PEVET, P ;
SASSONECORSI, P .
NATURE, 1993, 362 (6417) :264-267
[5]   BAX-DEFICIENT MICE WITH LYMPHOID HYPERPLASIA AND MALE GERM-CELL DEATH [J].
KNUDSON, CM ;
TUNG, KSK ;
TOURTELLOTTE, WG ;
BROWN, GAJ ;
KORSMEYER, SJ .
SCIENCE, 1995, 270 (5233) :96-99
[6]  
MIYASHITA T, 1995, CELL, V80, P293
[7]   Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice [J].
Nantel, F ;
Monaco, L ;
Foulkes, NS ;
Masquilier, D ;
LeMeur, M ;
Henriksen, K ;
Dierich, A ;
Parvinen, M ;
SassoneCorsi, P .
NATURE, 1996, 380 (6570) :159-162
[8]   MICE WITH REDUCED LEVELS OF P53 PROTEIN EXHIBIT THE TESTICULAR GIANT-CELL DEGENERATIVE SYNDROME [J].
ROTTER, V ;
SCHWARTZ, D ;
ALMON, E ;
GOLDFINGER, N ;
KAPON, A ;
MESHORER, A ;
DONEHOWER, LA ;
LEVINE, AJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (19) :9075-9079
[9]   Transcriptional checkpoints determining the fate of male germ cells [J].
SassoneCorsi, P .
CELL, 1997, 88 (02) :163-166
[10]   Transcription factors responsive to cAMP [J].
SassoneCorsi, P .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1995, 11 :355-377