Immunotherapy for pancreatic cancer: chasing the light at the end of the tunnel

被引：17

作者：

Brouwer, Thomas P. ^{[1
,2
,3
]}

Vahrmeijer, Alexander L. ^{[1
]}

de Miranda, Noel F. C. C. ^{[2
,3
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Pathol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Dept Pathol, POB 9600, NL-2300 RC Leiden, Netherlands

来源：

CELLULAR ONCOLOGY | 2021年 / 44卷 / 02期

基金：

欧盟地平线“2020”;

关键词：

Pancreatic ductal adenocarcinoma; PDAC; Immunotherapy; Microenvironment; Checkpoint blockade; Stroma; combination therapies; COLONY-STIMULATING FACTOR; FOCAL ADHESION KINASE; CAR T-CELLS; TUMOR-ASSOCIATED MACROPHAGES; MISMATCH REPAIR DEFICIENCY; TISSUE GROWTH-FACTOR; II CLINICAL-TRIAL; PHASE-I; DUCTAL ADENOCARCINOMA; SUPPRESSOR-CELLS;

D O I：

10.1007/s13402-021-00587-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Checkpoint blockade immunotherapy has had a significant impact on the survival of a subset of patients with advanced cancers. It has been particularly effective in immunogenic cancer types that present large numbers of somatic mutations in their genomes. To date, all conventional immunotherapies have failed to produce significant clinical benefits for patients diagnosed with pancreatic cancer, probably due to its poor immunogenic properties, including low numbers of neoantigens and highly immune-suppressive microenvironments. Conclusions Herein, we discuss advances that have recently been made in cancer immunotherapy and the potential of this field to deliver effective treatment options for pancreatic cancer patients. Preclinical investigations, combining different types of therapies, highlight possibilities to enhance anti-tumor immunity and to generate meaningful clinical responses in pancreatic cancer patients. Results from completed and ongoing (pre)clinical trials are discussed.

引用

页码：261 / 278

页数：18

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