Cyclotides as templates in drug design

被引：126

作者：

Henriques, Sonia Troeira ^{[1
,2
]}

Craik, David J. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[2] Univ Lisbon, Sch Med, Inst Mol Med, P-1649028 Lisbon, Portugal

来源：

DRUG DISCOVERY TODAY | 2010年 / 15卷 / 1-2期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

CYCLIC-CYSTINE-KNOT; POLYPEPTIDE KALATA B1; ANTI-HIV CYCLOTIDES; OLDENLANDIA-AFFINIS; CYCLOVIOLACIN O2; ANTIMICROBIAL PEPTIDES; STRUCTURAL MOTIF; PLANT CYCLOTIDES; CIRCULAR MINIPROTEINS; INSECTICIDAL ACTIVITY;

D O I：

10.1016/j.drudis.2009.10.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cyclotides are remarkably stable proteins from plants that have a range of pharmaceutical and agricultural applications based on both their various bioactivities and their potential for use as stable protein-engineering templates. This article discusses literature on pharmaceutically relevant activities of cyclotides, including anti-HIV, antimicrobial and cytotoxic activities, and evaluates their potential therapeutic applications. Their applications as templates for the design of antiangiogenic agents for the treatment of cancer and as anti-infective agents are also described. Toxic effects of cyclotides, whose native function is as insecticidal agents, can be removed by simple mutagenesis, thus rationalizing the apparent conundrum of proposing insecticidal agents as leads for human therapeutics.

引用

页码：57 / 64

页数：8

共 68 条

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