共 202 条
Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation
被引:472
作者:

Berkes, J
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机构: Univ Illinois, Dept Med, Sect Digest Dis & Nutr, Chicago, IL 60612 USA

Viswanathan, VK
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机构: Univ Illinois, Dept Med, Sect Digest Dis & Nutr, Chicago, IL 60612 USA

Savkovic, SD
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机构: Univ Illinois, Dept Med, Sect Digest Dis & Nutr, Chicago, IL 60612 USA

Hecht, G
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机构: Univ Illinois, Dept Med, Sect Digest Dis & Nutr, Chicago, IL 60612 USA
机构:
[1] Univ Illinois, Dept Med, Sect Digest Dis & Nutr, Chicago, IL 60612 USA
[2] W Side Vet Adm Med Ctr, Chicago, IL 60612 USA
来源:
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D O I:
10.1136/gut.52.3.439
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
The effects of pathogenic organisms on host intestinal epithelial cells are vast. Innumerable signalling pathways are triggered leading ultimately to drastic changes in physiological functions. Here, the ways in which enteric bacterial pathogens utilise and impact on the three major physiological functions of the intestinal epithelium are discussed: alterations in the structure and function of the tight junction barrier, induction of fluid and electrolyte secretion, and activation of the inflammatory cascade. This field of investigation, which was virtually non-existent a decade ago, has now exploded, thus rapidly expanding our understanding of bacterial pathogenesis. Through increased delineation of the ways in which microbes alter host physiology, we simultaneous gain insight into the normal regulatory mechanisms of the intestinal epithelium.
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页码:439 / 451
页数:13
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