Chemoselective debenzylation involving removal of a 2-hydroxy-1-phenylethyl group from nitrogen

被引：26

作者：

Fains, O ^{[1
]}

Vernon, JM ^{[1
]}

机构：

[1] UNIV YORK,DEPT CHEM,YORK YO1 5DD,N YORKSHIRE,ENGLAND

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(97)10163-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In 2-(2-hydroxy-1-phenylethyl)-1-isoindolinone, selective removal of the 2-hydroxy-1-phenylethyl group is conveniently achieved via a 3-step sequence (mesylation, elimination, hydrolysis) without breaking an endocyclic benzylic nitrogen bond. (C) 1997 Elsevier Science Ltd.

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页码：8265 / 8266

页数：2

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