Pediatric Bacterial Meningitis Surveillance in Nigeria From 2010 to 2016, Prior to and During the Phased Introduction of the 10-Valent Pneumococcal Conjugate Vaccine

被引：16

作者：

Tagbo, Beckie N. ^{[1
,2
]}

Bancroft, Rowan E. ^{[3
]}

Fajolu, Iretiola ^{[4
,5
]}

Abdulkadir, Mohammed B. ^{[6
]}

Bashir, Muhammad F. ^{[7
]}

Okunola, Olusola P. ^{[8
]}

Isiaka, Ayodeji H. ^{[9
]}

Lawal, Namadi M. ^{[10
]}

Edelu, Benedict O. ^{[2
]}

Onyejiaka, Ngozi ^{[11
]}

Ihuoma, Chinonyerem J. ^{[12
]}

Ndu, Florence ^{[13
]}

Ozumba, Uchenna C. ^{[12
]}

Udeinya, Frances ^{[12
]}

Ogunsola, Folasade ^{[11
]}

Saka, Aishat O. ^{[8
]}

Fadeyi, Abayomi ^{[14
]}

Aderibigbe, Sunday A. ^{[15
]}

Abdulraheem, Jimoh ^{[14
]}

Yusuf, Adamu G. ^{[16
]}

Ndow, Peter Sylvanus ^{[3
]}

Ogbogu, Philomena ^{[17
]}

Kanu, Chinomnso ^{[18
]}

Emina, Velly ^{[19
]}

Makinwa, Olajumoke J. ^{[11
]}

Gehre, Florian ^{[20
]}

Yusuf, Kabir ^{[10
]}

Braka, Fiona ^{[2
,21
]}

Mwenda, Jason M. ^{[22
]}

Ticha, Johnson M. ^{[9
]}

Nwodo, Dorothy ^{[9
]}

Worwui, Archibald ^{[3
]}

Biey, Joseph N. ^{[22
]}

Kwambana-Adams, Brenda A. ^{[3
]}

Antonio, Martin ^{[3
,23
]}

机构：

[1] Univ Nigeria, Teaching Hosp, Inst Child Hlth, Ituku Ozalla, Nigeria

[2] Univ Nigeria, Teaching Hosp Ituku Ozalla, Dept Paediat, Ituku Ozalla, Enugu State, Nigeria

[3] London Sch Hyg & Trop Med, WHO, Collaborating Ctr New Vaccines Surveillance, Med Res Council Unit Gambia, Banjul, Gambia

[4] Univ Lagos, Teaching Hosp, Dept Paediat, Lagos, Nigeria

[5] Univ Lagos, Coll Med, Dept Paediat, Lagos, Nigeria

[6] Univ Ilorin, Teaching Hosp, Dept Paediat & Child Hlth, Ilorin, Nigeria

[7] Abubakar Tafawa Balewa Univ, Teaching Hosp, Dept Paediat, Bauchi, Nigeria

[8] Univ Benin, Teaching Hosp, Dept Child Hlth, Cotonou, Benin

[9] WHO, Country Off, Abuja, Nigeria

[10] Natl Primary Hlth Care Dev Agcy, Dept Dis Control & Immunizat, Abuja, Nigeria

[11] Lagos Univ, Teaching Hosp, Dept Med Microbiol & Parasitol, Lagos, Nigeria

[12] Univ Nigeria, Teaching Hosp, Dept Microbiol, Ituku Ozalla, Enugu State, Nigeria

[13] Mother Christ Specialist Hosp Enugu, Enugu, Nigeria

[14] Univ Ilorin, Teaching Hosp, Dept Med Microbiol & Parasitol, Kwara, Nigeria

[15] Univ Ilorin, Teaching Hosp, Dept Epidemiol & Community Hlth, Kwara, Nigeria

[16] Abubakar Tafawa Balewa Univ, Teaching Hosp, Med Microbiol Dept, Bauchi, Nigeria

[17] Univ Benin, Teaching Hosp, Dept Med Microbiol, Cotonou, Benin

[18] Univ Benin, Teaching Hosp, Dept Community Hlth, Cotonou, Benin

[19] Lagos Univ, Teaching Hosp, Dept Community Hlth & Primary Care, Lagos, Nigeria

[20] Bernhard Nocht Inst Trop Med, Dept Infect Dis Epidemiol, Hamburg, Germany

[21] WHO, Abuja, Germany

[22] WHO, Reg Off Africa, AFRO, Brazzaville, Rep Congo

[23] Univ Warwick, Warwick Med Sch, Microbiol & Infect Unit, Coventry, W Midlands, England

来源：

CLINICAL INFECTIOUS DISEASES | 2019年 / 69卷

关键词：

pediatric; meningitis; Nigeria; pneumococcus; meningococcus; INFLUENZAE TYPE-B; STREPTOCOCCUS-PNEUMONIAE; CHILDREN; DISEASE; REPLACEMENT; MALARIA;

D O I：

10.1093/cid/ciz474

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Historically, Nigeria has experienced large bacterial meningitis outbreaks with high mortality in children. Streptococcus pneumoniae (pneumococcus), Neisseria meningitidis (meningococcus), and Haemophilus influenzae are major causes of this invasive disease. In collaboration with the World Health Organization, we conducted longitudinal surveillance in sentinel hospitals within Nigeria to establish the burden of pediatric bacterial meningitis (PBM). Methods. From 2010 to 2016, cerebrospinal fluid was collected from children <5 years of age, admitted to 5 sentinel hospitals in 5 Nigerian states. Microbiological and latex agglutination techniques were performed to detect the presence of pneumococcus, meningococcus, and H. influenzae. Species-specific polymerase chain reaction and serotyping/grouping were conducted to determine specific causative agents of PBM. Results. A total of 5134 children with suspected meningitis were enrolled at the participating hospitals; of these 153 (2.9%) were confirmed PBM cases. The mortality rate for those infected was 15.0% (23/153). The dominant pathogen was pneumococcus (46.4%: 71/153) followed by meningococcus (34.6%: 53/153) and H. influenzae (19.0%: 29/153). Nearly half the pneumococcal meningitis cases successfully serotyped (46.4%: 13/28) were caused by serotypes that are included in the 10-valent pneumococcal conjugate vaccine. The most prevalent meningococcal and H. influenzae strains were serogroup W and serotype b, respectively. Conclusions. Vaccine-type bacterial meningitis continues to be common among children <5 years in Nigeria. Challenges with vaccine introduction and coverage may explain some of these finding. Continued surveillance is needed to determine the distribution of serotypes/groups of meningeal pathogens across Nigeria and help inform and sustain vaccination policies in the country.

引用

页码：S81 / S88

页数：8

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