Liver injury associated with the use of Fructus Psoraleae (Bol-gol-zhee or Bu-gu-zhi) and its related proprietary medicine

被引：134

作者：

Cheung, Wing I. ^{[1
]}

Tse, Man Li ^{[2
]}

Ngan, Teresa ^{[3
]}

Lin, Jieru ^{[3
]}

Lee, Ws Ken ^{[3
]}

Poon, Wing Tat ^{[4
]}

Mak, Tony Wl ^{[4
]}

Leung, Vincent King Sun ^{[1
]}

Chau, Tai Nin ^{[1
]}

机构：

[1] United Christian Hosp, Dept Med & Geriatr, Div Gastroenterol & Hepatol, Hong Kong, Hong Kong, Peoples R China

[2] United Christian Hosp, Hosp Author, Hong Kong Poison Informat Ctr, Hong Kong, Hong Kong, Peoples R China

[3] Hosp Author, Chief Pharmacists Off, Chinese Med Sect, Hong Kong, Hong Kong, Peoples R China

[4] Princess Margaret Hosp, Hosp Author, Toxicol Reference Lab, Dept Pathol, Hong Kong, Hong Kong, Peoples R China

来源：

CLINICAL TOXICOLOGY | 2009年 / 47卷 / 07期

关键词：

Fructus Psoraleae; Herbs; Bol-gol-zhee; Bu-gu-zhi; Liver injury; HEPATITIS;

D O I：

10.1080/15563650903059136

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Fructus Psoraleae (FP) is used by herbalists for the treatment of postmenopausal osteoporosis, vitiligo, and psoriasis. It is used alone, or in combination with other herbs, in some countries in the form of proprietary medicine. It is recognized as one of the emerging hepatotoxins and here we report three cases of acute hepatitis after exposed to FP and its related proprietary medicine. It seems possible that psoralen and its related chemicals may be responsible for the hepatotoxicity. Decoction with other herbs may result in higher concentration of toxic constituents and in more severe liver injury. In summary, FP is associated with hepatotoxicity in some individuals. Pharmacovigilance for the potential side effects of herbal products is necessary.

引用

页码：683 / 685

页数：3

共 12 条

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