SINGLE-CENTER EXPERIENCE: Immunosuppressive Therapy as Frontline Treatment for 33 Children with Acquired Severe Aplastic Anemia

被引：11

作者：

Huang, I-Anne ^{[1
,2
]}

Jaing, Tang-Her ^{[1
,2
]}

Yang, Chao-Ping ^{[1
,2
]}

Hung, Iou-Jih ^{[1
,2
]}

Tsay, Pei-Kwei ^{[3
,4
]}

Luo, Chih-Cheng ^{[3
,4
]}

Sun, Chien-Feng ^{[5
]}

机构：

[1] Chang Gung Univ, Chang Gung Mem Hosp, Div Hematol, Tao Yuan, Taiwan

[2] Chang Gung Univ, Chang Gung Mem Hosp, Div Oncol, Tao Yuan, Taiwan

[3] Chang Gung Univ, Coll Med, Dept Publ Hlth, Tao Yuan, Taiwan

[4] Chang Gung Univ, Coll Med, Ctr Biostat, Tao Yuan, Taiwan

[5] Chang Gung Univ, Chang Gung Mem Hosp, Dept Clin Pathol, Tao Yuan, Taiwan

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2009年 / 26卷 / 07期

关键词：

frontline therapy; hematopoietic stem cell transplantation; immunosuppressive therapy; severe aplastic anemia; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; ANTITHYMOCYTE GLOBULIN; STIMULATING FACTOR; CYCLOSPORINE;

D O I：

10.1080/08880010902772364

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The authors retrospectively analyzed the records of 33 children with acquired severe aplastic anemia (SAA) diagnosed from July 1998 to October 2007 and first treated by immunosuppressive therapy (IST). Serial hematologic parameters, complications, transfusion requirements, and time to response were assessed. Allogeneic hematopoietic stem cell transplantation (HSCT) was attempted in 7 patients after failure of IST (n = 6) or relapse following an initial response to IST (n = 1). One child died of post-transplant lymphoproliferative disorder. Thirty of the 33 patients are alive and well after a median follow-up of 45 months (range, 7-116 months). Overall (transfusion-independent) response to IST was 73% (24/33). The actuarial 5 years survival rate was 89.4%. In this study, all patients with SAA received IST as standard front-line therapy. Approximately three-fourths of patients with SAA have durable recovery and excellent overall survival.

引用

页码：487 / 495

页数：9

共 23 条

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