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Historical Perspective of Eukaryotic DNA Replication
被引:7
作者:
Kelly, Thomas
[1
]
机构:
[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, 1275 York Ave, New York, NY 10021 USA
来源:
DNA REPLICATION: FROM OLD PRINCIPLES TO NEW DISCOVERIES
|
2017年
/
1042卷
关键词:
DNA replication;
Eukaryotes;
Viral models;
Origin of DNA replication;
Prereplicative complex;
Helicase;
Initiator;
Replisome;
ORIGIN RECOGNITION COMPLEX;
CELL NUCLEAR ANTIGEN;
LICENSING FACTOR CDT1;
IN-VITRO REPLICATION;
MINICHROMOSOME MAINTENANCE PROTEIN;
CDK-DEPENDENT PHOSPHORYLATION;
SV40;
DNA;
ADENOVIRUS DNA;
S-PHASE;
T-ANTIGEN;
D O I:
10.1007/978-981-10-6955-0_1
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The replication of the genome of a eukaryotic cell is a complex process requiring the ordered assembly of multiprotein replisomes at many chromosomal sites. The process is strictly controlled during the cell cycle to ensure the complete and faithful transmission of genetic information to progeny cells. Our current understanding of the mechanisms of eukaryotic DNA replication has evolved over a period of more than 30 years through the efforts of many investigators. The aim of this perspective is to provide a brief history of the major advances during this period.
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页码:1 / 41
页数:41
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